Relationship between elastase and total antioxidant status in young subjects with recent myocardial infarction

Article type: Research Article

Authors: Lo Presti, Rosalia | Montana, Maria | Canino, Baldassare | Amodeo, Gabriella | Lucido, Daniela | Romano, Adele | Catania, Anna | Caimi, Gregorio

Affiliations: Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Università di Palermo, Palermo, Italy

Note: [] Corresponding author: Prof. Gregorio Caimi, Via Leonardo da Vinci 52, 90145 Palermo, Italy. Fax: +39 91 6554535; E-mail: caimigre@unipa.it.

Abstract: In a group of young subjects with acute myocardial infarction (AMI) (68 men and 7 women; mean age 39.6±5.7 years) we examined the plasma concentration of elastase, the thiobarbituric acid-reactive substances (TBARS) and the total antioxidant status (TAS) at the initial stage of AMI. In this group we found an increase of elastase (p<0.001) and TBARS (p<0.001) and a decrease of TAS (p<0.001). A statistical correlation was observed in the whole group of AMI patients between plasma elastase and TAS (p<0.01) and this correlation was more statistically significant in patients with more risk factors and not in those with more involved vessels.

Keywords: Juvenile myocardial infarction, plasma elastase, total antioxidant status

DOI: 10.3233/CH-2008-1060

Journal: Clinical Hemorheology and Microcirculation, vol. 40, no. 1, pp. 31-36, 2008