Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Yada, Toyotaka; | Kaji, Shuichiro | Akasaka, Takashi | Mochizuki, Seiichi | Ogasawara, Yasuo | Tanemoto, Kazuo | Yoshida, Kiyoshi | Kajiya, Fumihiko
Affiliations: Department of Medical Engineering and Systems Cardiology, Kawasaki Medical School, Kurashiki, Japan | Division of Cardiovascular Medicine, Kawasaki Medical School, Kurashiki, Japan | Department of Thoracic and Cardiovascular Surgery, Kawasaki Medical School, Kurashiki, Japan | Department of Cardiology, Kobe General Hospital, Kobe, Japan | Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
Note: [] Corresponding author. E-mail: yada@me.kawasaki-m.ac.jp.
Abstract: The relationship among the nitric oxide synthase (NOS) inhibitor [asymmetric dimethylarginine (ADMA)], NOS cofactor [tetrahydrobiopterin (BH4)], and superoxide anion in the patients with acute myocardial infarction (AMI) is still unknown. This study sought to assess the NOS inhibitor and cofactor with oxidative stress in AMI patients (n=9) during initial administration and 4 weeks after medical treatments. We measured plasma NOS inhibitor and cofactor (ADMA and BH4) by HPLC and plasma oxidized-LDL by ELISA. Blood samples from age-matched healthy volunteers (n=9) were taken for comparison. In AMI, plasma ADMA, oxidized-BH4 (BH2+biopterin) and oxidized-LDL significantly increased (P<0.0001, P<0.01 and P<0.05 vs. healthy volunteers) and plasma BH4, plasma nitrate and L-arginine/ADMA significantly decreased compared with healthy volunteers (P<0.0001, P<0.05 and P<0.005 vs. healthy volunteers). Medical treatments improved plasma ADMA, nitrate, BH4 and oxidized-LDL. In conclusion, ADMA increased, and NO and BH4 decreased with oxidative stress in AMI, and these mediators improved in AMI patients with medical treatments. These findings indicated that inhibition of NOS with oxidative stress plays a crucial role in endothelial dysfunction in patients with AMI.
Keywords: AMI, NOS, ADMA, BH_4, oxidative stress
Journal: Clinical Hemorheology and Microcirculation, vol. 37, no. 3, pp. 269-276, 2007
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl