The ideal small arterial substitute: Role of cell seeding and tissue engineering
Issue title: Selected Papers from 1st Meeting on “Cardiovascular Biology: Endothelial Cell in Health and Hypertension”, 30 June–1 July 2006, Prague, Czech Republic
Affiliations: Mécanique et Ingénierie Cellulaire et Tissulaire, LEMTA-UMR 7563, IFR 111, Faculté de Médecine Université Henry Poincaré, 54505 Vandoeuvre-lès-Nancy, France | INSERM U577, Bordeaux, F-33076 France, Université Victor Segalen, Bordeaux 2, Bordeaux F33076, France
Note: [] Both authors contributed equally to this work.
Note: [] Corresponding authors: H. Kerdjoudj and V. Moby, Laboratoire de Mécanique et Ingénierie Cellulaire et Tissulaire, Faculté de Médecine Université Henri Poincaré, Nancy 1, 54505 Vandoeuvre-lès-Nancy, France. Tel.: +33 3 83 68 34 67, Fax: + 33 3 83 68 34 59; E-mail: halima.kerdjoudj@medecine.uhp-nancy.fr, vanessa.moby@medecine.uhp-nancy.fr.
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Abstract: Although autogenous vessels are useful in surgery, often patients cannot furnish suitable vessels. If there are not available, two possible alternatives for vessel replacements are to use vascular synthetic prostheses such as Dacron® and polytetrafluoroethylene (PTFE) or cryopreserved allografts. However, their success has been limited to replace small-diameter (<6 mm) arterial vessel because of their high thrombogenicity and compliance mismatch. On account of a clear clinical need for a functional arterial substitute, tissue engineering techniques have been developed. This review encompasses the use of mature endothelial, endothelial progenitor and bone marrow cells combined with natural or synthetic scaffolds whose surface has been modified with multiple origin matrices.
