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Article type: Research Article
Authors: Kenny, M.W. | Meakin, M. | Stuart, J.; *
Affiliations: Department of Haematology, The Medical School, University of Birmingham, Birmingham B15 2TJ, UK
Correspondence: [*] Correspondence to Professor J. Stuart
Note: [] Accepted by: Editor J. Dormandy
Abstract: A positive-pressure, washed-erythrocyte method for the measurement of red cell filterability has been compared with a negative-pressure, whole-blood technique. Using 5 µm pore-size polycarbonate filters, both methods detected a sub-population of 4–5 × 107/l glutaraldehyde-hardened erythrocytes and both showed a decrease in erythrocyte filterability in proportion to increasing concentrations of added fibrinogen. The washed-erythrocyte method gave better reproducibility with less variation between filter batches and is recommended for the study of patients in whom plasma hyperproteinaemia may adversely affect erythrocyte filtration.
Keywords: Erythrocyte filterability, Blood viscosity
DOI: 10.3233/CH-1981-1204
Journal: Clinical Hemorheology and Microcirculation, vol. 1, no. 2, pp. 135-146, 1981
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