Analysis of the specific hemorheological effects of low molecular weight dextran (LMWD)- and saline-infusions in healthy volunteers

Article type: Research Article

Authors: Ehrly, Albrecht M. | Landgraf, Helmut

Affiliations: Department of Angiology, Johann-Wolfgang-Goethe-University Frankfurt am Main, F.R. Germany

Note: [] Accepted by: Editor A.L. Copley

Abstract: The flow properties of blood were measured with various methods (rheologic analysis battery) before and after the infusion of 500 ml of a) 10 % low molecular weight dextran solution and b) of a 0,9 % sodium chloride solution in healthy volunteers. LMWD decreases blood viscosity, but increases plasma viscosity. Red cell filtration is decreased. There is no specific disaggregating effect of LMWD. After infusion of saline there is a transient decrease in blood and plasma viscosity, and an increase in filtration rate. No specific reduction in red cell aggregation could be found.

Keywords: Hemorheology, Low molecular weight dextran, Physiological saline

DOI: 10.3233/CH-1981-1106

Journal: Clinical Hemorheology and Microcirculation, vol. 1, no. 1, pp. 99-109, 1981