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Article type: Research Article
Authors: Yamaguchi, Saburo | Yamakawa, Takashi | Niimi, Hideyuki
Affiliations: Department of Microcirculatory Science, National Cardiovascular Center Research Institute, Suita, Osaka 565, Japan
Note: [] Accepted by: Editor P. Gaehtgens
Abstract: Two diameters of vessel and red cell column in cerebral microvessels (> 29.8 μm in diameter) of cat were measured together with red cell velocity, using a two fluorescent tracer method. A fluorescein isothiocyanate (FITC)-labelled red cell was adopted as a flow tracer to measure the cell velocity with a dual window technique. Based on the fluorescence image, the red cell column diameter was measured. Plasma was stained with rhodamine-B isothiocyanate (RITC)-labelled dextran to measure the vessel diameter. The thickness of the cell-free plasma layer could be determined from the difference of the two diameters. The obtained thickness of the cell-free layer was not described by a simple function of vessel diameter or red cell velocity; it was dependent on the pseudo shear rate defined by the ratio of cell velocity to vessel radius. The layer thickness increased with a decrease in the pseudo shear rate.
Keywords: cell-free layer, red cell velocity, pseudo shear rate, cerebral microcirculation, intravital fluorescence microscopy
DOI: 10.3233/BIR-1992-292-305
Journal: Biorheology, vol. 29, no. 2-3, pp. 251-260, 1992
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