Contributions to biorheology during hemodialysis

Article type: Research Article

Authors: Seyfert, U.T.^a | Hauck, W.^a | Kirsch, J.^b | Kiesewetter, H.^a | Albert, F.W.^b | Wenzel, E.^a

Affiliations: [a] Abt. für Klinische Hämostaseologie und Transfusionsmedizin, Unikliniken, D - 6650 Hornburg/Saar, FRG | [b] Med. Klinik III, Staedt.Krankenhaus Kaiserslautern, D - 6750 Kaiserslautern,F FRG

Note: [] Accepted by: Editor J.-F. Stoltz

Abstract: Thrombogenecity is the property of a foreign surface to induce clotting processes or formation of aggregates after contact with blood. Beside the sort of anticoagulation patient’s prethrombotic state, rheological factors as well as physicochemical properties of foreign membranes decisively influence thrombogenecity. We examined the influence of chronic renal failure and different hemodialyzers and blood transfusion therapy during hemodialysis on hemorheological parameters. Different membranes cannot be discriminated by the used hemorheological parameters. We clearly could demonstrate the close relationship between the hemofiltration rate and an increase of viscosity. Blood transfusion therapy or elevated hematocrit in combination with increased hemofiltration rate have influence on the flow behaviour of blood especially in disturbed microcirculation.

Keywords: biocompatibility, hemodialysis, biorheology, hemodialyzer, blood transfusion

DOI: 10.3233/BIR-1991-28510

Journal: Biorheology, vol. 28, no. 5, pp. 473-481, 1991