Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Weiss, Leonard | Harlos, James P. | Elkin, Galina
Affiliations: Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Note: [] Accepted by: Editor H.L. Goldsmith
Abstract: Ehrlich ascites cancer cells were compressed between glass microscope slides by the addition of weights. The projected areas of the cells were measured, and their surface membrane integrity determined by means of trypan-blue exclusion tests under different compression loads of 0 to 800g. The results are compatible with a two-step mechanism for surface rupture; first the cell membrane is unfolded and then stretched, with modest degrees of stretching associated with membrane rupture. It is calculated that lethal surface membrane rupture of the type produced here by compression, could also be produced when cancer cells are deformed by entry and passage along relatively non-deformable capillaries. This would at least partially account for the rapid destruction of cancer cells in the microcirculation. The observation that isolated nuclei are less deformable than whole cells, may indicate that their nuclei may protect cancer cells from biomechanical trauma.
Keywords: Cell compression, metastasis, lethal damage, metastatic inefficiency
DOI: 10.3233/BIR-1991-283-410
Journal: Biorheology, vol. 28, no. 3-4, pp. 185-193, 1991
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl