Diagnostic and therapeutic applications of antiplatelet monoclonal antibodies

Article type: Research Article

Authors: Coller, Barry S.

Affiliations: Division of Hematology, State University of New York at Stony Brook, Stony Brook, NY 11794

Note: [] Accepted by: Editor S. Chien

Abstract: The interaction of platelets with natural and artificial surfaces is briefly reviewed, emphasizing the role of the platelet glycoprotein Ib and IIb/IIIa receptors. Studies utilizing monoclonal antibodies to these receptors for the diagnosis and therapy of hemorrhagic and thrombotic disorders are described, indicating the potential of such agents as platelet inhibitors.

Keywords: Platelet, Fibrinogen, GPIb, GPIIb/IIIa Monoclonal Antibody

DOI: 10.3233/BIR-1987-24618

Journal: Biorheology, vol. 24, no. 6, pp. 649-658, 1987