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Article type: Research Article
Authors: Urban, J.P.G.a | Maroudas, A.a | Bayliss, M.T.b | Dillon, J.a
Affiliations: [a] Bone and Joint Research Unit, Arthritis and Rheumatism Council Building, The London Hospital Medical College, London El 2AD | [b] Experimental Pathology Unit, Institute of Orthopaedics, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex
Note: [] Accepted by: Editor R.D. Harkness
Abstract: The osmotic pressure of proteoglycans extracted from human hip, knee and intervertebral disc cartilage and from bovine nasal cartilage, and of chondroitin sulphate was measured by equilibrium dialysis against solutions of polyethylene glycol in 0.15M NaCl and 1.5M NaCl. The osmotic pressure of the proteoglycans at concentrations found in these cartilaginous tissues, viz. 0.08–0.35 meq/gH2O, was found to lie in the range 0.3–3.5 atm. Molecular size and degree of aggregation were found to have no measurable influence on the value of osmotic pressure. The “Donnan” osmotic pressure was by far the major component; under physiological conditions, not more than 15 per cent of the total osmotic pressure resulted from excluded volume effects.
Keywords: Osmotic pressure, proteoglycans, glycosaminoglycans, articular cartilage, intervertebral disc and chondroitin sulphate
DOI: 10.3233/BIR-1979-16609
Journal: Biorheology, vol. 16, no. 6, pp. 447-464, 1979
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