Elevation of plasma viscosity and of aggregation of red cells in melanoma metastasis

Article type: Research Article

Authors: Dintenfass, L.

Affiliations: Haemorheology Department, Medical Research, Kanematsu Memorial Institute, Sydney Hospital, Sydney 2000, and Department of Medicine, University of Sydney, Sydney 2006, Australia

Note: [] Accepted by: Editor A.L. Copley

Abstract: A study of blood and plasma viscosities and of aggregation of red cells in 125 patients with malignant melanoma indicated that patients who died subsequently of metastasis showed a significant elevation of plasma viscosity and of aggregation of red cells. Plots of plasma viscosity or of aggregation of red cells against the time interval between test and subsequent death showed significant and negative correlations. Plots of plasma viscosity against globulin level, and plots of aggregation of red cells against albumin/fibrinogen ratio, showed significant differences between slopes of linear regressions for the survivors and for the deceased group.

DOI: 10.3233/BIR-1978-15204

Journal: Biorheology, vol. 15, no. 2, pp. 99-110, 1978