Affiliations: Biomedical Engineering Center, The Ohio State University, Columbus, OH 43210, USA
Note: [] Corresponding author: Dr. Morton H. Friedman, 270 Bevis Hall, 1080 Carmack Road, Columbus, OH 43210, USA. Tel.: +1 614 292 7160; Fax: +1 614 292 7301; E‐mail: friedman.1@osu.edu.
Abstract: Experiments were carried out in swine to test the hypothesis that changes in the fluid dynamic environment of the arterial wall, with time constants of several minutes to perhaps a few hours, prompt adaptive responses that transiently increase endothelial permeability. After parenteral Evans Blue Dye (EBD) administration, the hemodynamics of the external iliac arteries of the experimental animals were altered using a reversible arteriovenous femoral shunt. For 3 h, the shunt was opened and closed with a period (τ) between 1–180 min. Subsequently, the animal was euthanized and the iliac vessels were photographed en face to obtain the distribution of EBD‐bound albumin uptake by the tissue during its exposure to the dye. Albumin uptake increases with τ in a fashion that can be explained by an a priori model of the adaptive permeability response, with a time constant of about an hour.
Keywords: Shear effects, vascular permeability, albumin, time constant
Journal: Biorheology, vol. 37, no. 4, pp. 265-277, 2000
