Cancer Biomarkers - Volume 26, issue 1

Authors: Singh, Preeti | Augustine, Dominic | Rao, Roopa S. | Patil, Shankargouda | Sowmya, Samudrala Venkatesiah | Haragannavar, Vanishri C. | Nambiar, Shwetha

Article Type: Research Article

Abstract: BACKGROUND: The Indian subcontinent has the highest incidence and prevalence of oral squamous cell carcinoma (OSCC). Inflammation and apoptosis are two emerging hall marks of cancer that might play a significant role in tumorigenesis and metastasis. Concurrent expression of proinflammatory cytokine (IL-1β ) and executioner caspase (Caspase-3) in same OSCC tissue samples has not been reported in an Indian population. OBJECTIVES: The present study aimed to evaluate the immunohistochemical expression of IL-1β and Caspase-3 in same OSCC tissue samples with clinicopathological correlation and survival analysis in Indian population. METHODS: …A retrospective study was conducted utilizing 40 formalin fixed paraffin embedded histologically diagnosed cases of OSCC comprising of 20 metastatic OSCC and 20 non-metastatic OSCC. RESULTS: Increased expression of IL-1β and Caspase-3 were observed in metastatic OSCC. Correlation of expression of IL-1β and Caspase-3 with clinicopathological parameters revealed a significant association between these markers and staging, nodal status and site of the lesion. CONCLUSION: Over expression of IL-1β and Caspase-3 was associated with advanced stage and poor survival of the patient. IL-1β overexpression showed significantly lower disease-free survival and disease specific survival as well. Overexpression of IL-1β and Caspase-3 in incisional OSCC biopsies could be considered for predicting metastasis and survival outcome. Show more

Keywords: Caspase-3, Interleukin-1β, mouth neoplasms, biologic behaviour, cumulative survival, survival analysis

DOI: 10.3233/CBM-190149

Citation: Cancer Biomarkers, vol. 26, no. 1, pp. 109-122, 2019