Bio-Medical Materials and Engineering - Volume 26, issue s1

Authors: Chen, Xiaoyan | Lv, Xinqiang | Wang, Huaxiang

Article Type: Research Article

Abstract: Lung carcinoma has become one of the malignancies whose morbidity and mortality are growing significantly. Blood is a functional body fluid, it delivers oxygen and nutrients to the other parts of the body, and it is a pathway of tumor metastasis. This paper studies the possibility of diagnosing lung carcinoma by blood dielectric spectroscopy. Comparison experiments were carried out to trace the dielectric spectroscopy of blood with and without lung carcinoma changing at different tumor stages from 100 Hz to 100 MHz. The research results show that the discrepancy of complex permittivity between rat blood with and without lung carcinoma …becomes significant with tumor growing, which is worthy for clinical diagnosis. Show more

Keywords: Lung carcinoma, dielectric spectroscopy, blood, noninvasive detection

DOI: 10.3233/BME-151382

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S895-S901, 2015

Authors: Yan, Yonggang | Ma, Xiang | Yao, Lifeng | Ouyang, Jianfei

Article Type: Research Article

Abstract: Non-contact and remote measurements of vital physical signals are important for reliable and comfortable physiological self-assessment. We presented a novel optical imaging-based method to measure the vital physical signals. Using a digital camera and ambient light, the cardiovascular pulse waves were extracted better from human color facial videos correctly. And the vital physiological parameters like heart rate were measured using a proposed signal-weighted analysis method. The measured HRs consistent with those measured simultaneously with reference technologies (r =0.94, p <0.001 for HR). The results show that the imaging–based method is suitable for measuring the physiological parameters, and provide a reliable …and comfortable measurement mode. The study lays a physical foundation for measuring multi-physiological parameters of human noninvasively. Show more

Keywords: Biomedical engineering, noncontact cardiovascular measurement, heart rate, blood pressure, pulse wave

DOI: 10.3233/BME-151383

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S903-S909, 2015

Authors: Luo, Binhua | Zhang, Huajie | Liu, Xuhan | Rao, Rong | Wu, Yun | Liu, Wei

Article Type: Research Article

Abstract: Fluorescence dye DiR and superparamagnetic iron oxide nanoparticles (SPIONs) embedded in PEG-PLGA nanobubbles (DiR-SPIO-NBs) were produced using double emulsion method on a membrane of Shirasu porous glass (SPG). The nanobubbles encapsulated with DiR and SPIONs had a liquid core (perfluoropentane) and a PEG-PLGA shell. DiR-SPIO-NBs showed biocompatibility based on MTT cytotoxicity and hemolysis studies. The PFP encapsulated in the nanobubbles experienced phase transition under ultrasonic irradation. Nanobubbles dispersed well in saline over 3 months, and the relaxivity was 127.9 mM−1 s−1 , suggesting that it could be used as a contrast agent in MRI. The MR and fluorescence images in …vivo demonstrated that the signal intensity in the spleen and liver was significantly enhanced with the treatment of nanobubbles. In addition, results of ultrasound images suggested that the nanobubbles had persistent contrast ability. In conclusion, nanobubbles could be utilized as an US/MRI/fluorescence contrast agent. Show more

Keywords: Nanobubbles, ultrasound-triggered phase transition, multimodal contrast agent, ultrasound imaging, magnetic resonance imaging, fluorescence imaging

DOI: 10.3233/BME-151384

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S911-S916, 2015

Authors: Wang, Dongcui | Mo, Fongming | Zhang, Yangde | Yang, Chao | Liu, Jun | Chen, Zhencheng | Zhao, Jinfeng

Article Type: Research Article

Abstract: In a previous study (unpublished), Emotiv headset was validated for capturing event-related potentials (ERPs) from normal subjects. In the present follow-up study, the signal quality of Emotiv headset was tested by the accuracy rate of discriminating Major Depressive Disorder (MDD) patients from the normal subjects. ERPs of 22 MDD patients and 15 normal subjects were induced by an auditory oddball task and the amplitude of N1, N2 and P3 of ERP components were specifically analyzed. The features of ERPs were statistically investigated. It is found that Emotiv headset is capable of discriminating the abnormal N1, N2 and P3 components in …MDD patients. Relief-F algorithm was applied to all features for feature selection. The selected features were then input to a linear discriminant analysis (LDA) classifier with leave-one-out cross-validation to characterize the ERP features of MDD. 127 possible combinations out of the selected 7 ERP features were classified using LDA. The best classification accuracy was achieved to be 89.66%. These results suggest that MDD patients are identifiable from normal subjects by ERPs measured by Emotiv headset. Show more

Keywords: Emotiv system, major depressive disorder, event-related potential

DOI: 10.3233/BME-151385

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S917-S923, 2015

Authors: Zhu, Junjiang | He, Lingsong | Du, Jianhao

Article Type: Research Article

Abstract: This paper improves the learning dictionary construction method for morphological component analysis (MCA) to separate the atrial and ventricular signals. The incoherence is added into the objective function to reduce the sparsity ratio between the atrial and ventricular dictionaries. By using the dictionaries, atrial and ventricular activities are separated from the location of the coefficients. We test the methods on both the synthetic and real atrial data. While extracting AFW from synthetic data, we use the Poisson relation as the measure. The result shows that we can obtain greater relation value using the method this paper presents than using the …methods of ABS and PCA. We also conduct spectral analysis on AFW extracted from real atrial data. Show more

Keywords: Atrial fibrillation wave, morphological component analysis, sparse, learned dictionary

DOI: 10.3233/BME-151386

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S925-S934, 2015

Authors: Lim, Seunghyun | Kim, Hyunho | Song, Haryong | Cho, Dong-il “Dan” | Ko, Hyoungho

Article Type: Research Article

Abstract: This paper presents an analog front-end (AFE) IC design for recording biopotential signals. The AFE employs a capacitively coupled instrumentation amplifier to achieve a low-noise and high-common mode rejection ratio (CMRR) system. A ripple reduction loop is proposed to reduce the ripple generated by the up-modulating chopper. The low frequency noise is attenuated by an input AC coupling capacitor, and is attenuated again by a DC servo loop. The proposed AFE features a differential gain of 71 dB, and a CMRR of 89 dB, at 50 Hz. Furthermore, the proposed AFE can robustly acquire biopotential signals even in the presence …of an input offset and ripples. Show more

Keywords: Biopotential analog front-end (AFE), electroencephalograph (EEG), electrocardiogram (ECG), ripple reduction loop, DC servo loop

DOI: 10.3233/BME-151387

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S935-S941, 2015

Authors: Zhi, Deng

Article Type: Research Article

Abstract: Fiducial Localization Error (FLE) is one of the major reasons of inaccuracy in point-based spatial registration of Image-Guided Neurosurgery System (IGNS), and minimizing FLE is the fundamental way to improve spatial registration accuracy. A reliable estimation of FLE is needed, as it cannot be measured directly in real application of IGNS. In this paper, we propose a method to estimate the FLE in a point-based registration of IGNS. Test fiducial point sets were generated in one coordinate system around the given fiducial point set by utilizing simple random sampling. Further, these points were registered to the fiducial point set in …the other coordinate system. The average position of the test fiducial point sets with small FRE are calculated and its displacement from the given fiducial point set is the parameter used to estimate the FLE of each fiducial point. The correlation between the displacement and the FLE of each fiducial point is greater than 0.75 when nine or more fiducial points were utilized. This correlation gradually increases up to 0.9 with the increase of the number of fiducial points. Show more

Keywords: Image-guided neurosurgery, fiducial localization error, point-based registration

DOI: 10.3233/BME-151388

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S943-S949, 2015

Authors: He, YiFan | Meng, Hong | Dong, YinMao

Article Type: Research Article

Abstract: Laser Doppler imagery is a contemporary form biomedical science specializing in non-evasive micro-circulation investigation. This paper outlines the process and results of applying twelve different test samples to mouse skin to collect data variation of micro-circulation, then judge the effects of different formulas in skin health improvement. More specifically, it is said [15] that micro-circulation is associated with anti-aging (otherwise known as micro-circulation acceleration) by the way of improvement of nutrition supply and hazard substance elimination, has some effects of skin anti-aging. In this paper, compared with Group 0 (the blank group), Group 1, and Group 2 formulas have …statistically significant differences in skin micro-circulation perfusion, which implies that those two groups are provided with better anti-aging formulas. So, Group 1’s formula and Group 2’s formula have the most significant positive effect on the skin health. Show more

Keywords: Laser doppler imager, skin micro-circulatory perfusion, skin health, Chinese medicine formulas

DOI: 10.3233/BME-151389

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S951-S958, 2015

Authors: Wu, Hao | Shen, Guofeng | Chen, Yazhu

Article Type: Research Article

Abstract: Electromagnetic compatibility (EMC) is a key issue in the design and development of safe and effective medical instruments. The treatment probes of high intensity focused ultrasound (HIFU) systems not only receive and transmit electromagnetic waves, but also radiate ultrasound waves, resulting in electromagnetic coupling. In this paper, an electromagnetic shielding method involving the enclosure of the probe in a copper wire mesh was introduced. First, sound pressure distribution simulations and measurements were performed using a hydrophone in order to evaluate the effects of the wire mesh on the acoustic performance of the HIFU system. The results indicated that the wire …mesh did not disturb the normalized sound pressure field. In addition, the attenuation of the maximum pressure in the focal plane was equal to 6.2%. Then, the electronic emission level was tested in a chamber. After the implementation of the wire mesh, the 10-100 MHz frequency band radiation was suppressed, and the HIFU system satisfied the national EMC standards. Show more

Keywords: High intensity focused ultrasound, electromagnetic compatibility, radiated emission, radio frequency shielding

DOI: 10.3233/BME-151390

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S959-S966, 2015

Authors: An, Yong | Wang, Manning | Song, Zhijian

Article Type: Research Article

Abstract: This study presents a novel spatial registration method of Image-guided neurosurgery system (IGNS) based on stereo-vision. Images of the patient’s head are captured by a video camera, which is calibrated and tracked by an optical tracking system. Then, a set of sparse facial data points are reconstructed from them by stereo vision in the patient space. Surface matching method is utilized to register the reconstructed sparse points and the facial surface reconstructed from preoperative images of the patient. Simulation experiments verified the feasibility of the proposed method. The proposed method it is a new low-cost and easy-to-use spatial registration method …for IGNS, with good prospects for clinical application. Show more

Keywords: Image-guided neurosurgery system, stereo vision, spatial registration, iterative closest point

DOI: 10.3233/BME-151391

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S967-S973, 2015