Affiliations: [a] Department of Elderly Neurology, Heilongjiang Province Hospital, Harbin, China | [b] Department of Neurology, the First Hospital, Jilin University, P.R. China | [c] Department of Neurology, Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, China | [d] Department of Neurology, Heilongjiang Province Hospital, Harbin, China
Correspondence:
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Address for correspondence: Jiachun Feng, Department of Neurology, the First Hospital, Jilin University, 71 Xinmin Street Changchun Jilin 130000, P.R. China. Tel.: +86 043188783520; Fax: +86 043188783521; E-mail: fengjcfrank@yahoo.com.cn
Abstract: Aim:To explore the role of rs11053646 polymorphism of oxidized low-density lipoprotein receptor 1 (OLR-1) gene in the susceptibility and prognosis of ischemic stoke (IS). Methods:A total of 304 IS patients and 377 age and sex-matched healthy controls were recruited. Patients were followed up for 6 months for recovery evaluation of stroke. Genotyping analyses of the rs11053646 G > C polymorphisms of OLR1 gene were performed. Results:The genotype frequencies and alleles frequencies at rs11053646 were significantly differed between stroke subjects and control subjects (both P < 0.001). The presence of CC genotype was significantly higher in IS subjects than in controls (38% vs. 25%, P = 0.001). Similarly, the C allele carriage in IS was significantly higher than controls (59% vs. 49%, P < 0.001). Regression analysis showed the CC homozygote had a significantly increased risk for stroke (adjusted OR = 2.080; P = 0.001). The genotype of rs11053646 were not associated with the IS subtype and severity at admission, but determine the clinical outcome at 6 months after discharge from hospital. Conclusion:The rs11053646 polymorphism of OLR1 gene be used as a molecular marker for the susceptibility and prognosis of IS in Chinese population.
