Intrathecal baclofen for spasticity of cerebral origin

Article type: Research Article

Authors: Laborde, Andrea T.^{; *} | Weibel, M.E. | Meythaler, Jay | Narayan, Raj

Affiliations: MossRehab Hospital, Philadelpia, PA, USA

Correspondence: [*] MossRehab Hospital, 1200 W. Tabor Road, Philadelphia, PA 19141, USA. Tel.: +1 215 456 9537; Fax: +1 215 456 9579

Abstract: This article provides an overview of the use of intrathecal baclofen in the treatment of spasticity due to cerebral origin. Oral and intrathecal uses of baclofen are compared. The unique pharmacological properties of baclofen which make it ideal for intrathecal use are discussed. Historical development of the treatment in both spinal and cerebral spasticity is presented. Technical aspects (performing trials, surgical insertion, and maintenance) and complications of treatment are reviewed. Through the use of case studies selection of candidates and concomitant treatment options are explored

Keywords: baclofen, infusion pump, intrathecal injection, spasticity, traumatic brain injury

DOI: 10.3233/NRE-1999-12202

Journal: NeuroRehabilitation, vol. 12, no. 2, pp. 81-91, 1999