Affiliations: Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA | Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA | Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA | Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA | Mayfield Clinic, Cincinnati, OH, USA
Note: [] Corresponding author: Todd A. Abruzzo, Department of Neurosurgery, 260 Stetson street, suite 2200, Cincinnati, OH 45219, USA. Tel.: +1 513 569 5214; Fax: +1 513 475 8628; E-mail: todd.abruzzo@cchmc.org.
Abstract: Intracranial arterial aneurysms are an important cause of hemorrhagic stroke during the first two decades of life. In the pediatric population, intracranial arterial aneurysms have a diverse etiological spectrum. The clinical course, response to treatment and long-term prognosis correlate strongly with the mechanism of lesion pathogenesis. A variety of phenotypes have been characterized, having variably overlapping features and differentiated according to the mechanism of pathogenesis: (1) idiopathic, (2) traumatic, (3) infectious, (4) flow related, (5) oncotic, (6) non-infectious inflammatory, (7) arteriopathic and (8) familial. The purpose of this report is to review intracranial aneurysmal disease in the pediatric population. We discuss contemporary approaches to diagnostic evaluation and clinical management, emphasizing interventional strategies and recent advances.
Keywords: Intracranial aneurysm, cerebral arterial diseases, arteriopathy, children
