Affiliations: Department of Radiology, Children’s Healthcare of Atlanta at Scottish Rite Atlanta, GA, USA | Departments of Radiology, Neuroscience, Pediatrics and Environmental Health, Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA
Note: [] Corresponding author: Laura L. Hayes, Children’s Healthcare of Atlanta at Scottish Rite, Department of Radiology, 1001 Johnson Ferry Road, NE, Atlanta, GA 30342, USA. Tel.: +1 404 785 3468; Fax: +1 404 785 4790; E-mail: Laura.hayes@choa.org.
Abstract: This article discusses some of the most commonly encountered compounds producing toxic leukoencephalopathies in infants, children and adolescents: opioids, methanol, ethylene glycol, carbon monoxide, and inhalants such as toluene, medications including methotrexate, cyclosporine, and tacrolimus. Toxic effects on white matter can produce a varied appearance on neuroimaging. The diagnosis of toxic leukoencephalopathies can be made by careful attention to the history, presentation, and neuroradiological findings.
