Affiliations: [a] School of Physical Education (FEF), State University
of Campinas (UNICAMP), Campinas, Brazil | [b] School of Physical Education and Sport (EEFE),
University of São Paulo (USP), São Paulo, Brazil | [c] Metrocamp, IBMEC Educational Group, Campinas,
Brazil
Note: [] Corresponding author: Miguel Soares Conceição,
Exercise Physiology Laboratory – FISEX, School of Physical Education,
University of Campinas – UNICAMP. Av Érico Veríssimo, 701
Zip Code: 13083-851 – P.O. Box 6134. Campinas, Brazil. Tel.: +55 19
35216625; Fax: +55 19 35216600; E-mail: conceicao.miguel0106@gmail.com
Abstract: OBJECTIVE: The present study aimed to verify the indirect markers of
muscle damage and inflammatory response following different velocities of
eccentric exercise in women. METHODS: Nine women performed isokinetic eccentric actions at a slow
velocity (Ecc30 group, 23.8 ± 2.0 years; 57.8 ± 7.0 Kg; 1.6
± 0.5 m) and another ten women performed at high velocity (Ecc210 group,
22.2 ± 3.9 years; 56.4 ± 6.0 Kg; 1.6 ± 0.5 m). Maximal
voluntary isometric contraction (MVIC), range of motion (ROM), upper-arm
circumference, muscle soreness, creatine kinase (CK), tumor necrosis
factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10)
were measured before, immediately after (except CK and cytokines), and 24, 48
and 72 h following exercise. Normalized changes in the variables following
exercise were compared between velocities by a mixed model. RESULTS: The Ecc30 demonstrated greater CK activity than the Ecc210
(group vs. time interaction, P< 0.001). A group effect for circumference and
ROM (P< 0.001) and a time effect for circumference (P=0.003), ROM (P=0.004),
soreness (P< 0.001), TNF-α (P=0.004), IL-6 (P=0.001) and IL-10
(P=0.041) were found. The Ecc30 showed large effect sizes for TNF-α and
IL-6 compared to Ecc210, which presented small and moderate effect sizes,
respectively. IL-10 showed a moderate effect size for both groups. CONCLUSIONS: The velocity of the eccentric exercise does not
modulate the systemic anti-inflammatory response, at least for a low number of
muscle contractions performed by a small muscle group in women.
