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Article type: Research Article
Authors: Eftekharian, Mohammad Mahdia | Ghannad, Masoud Sabourib; * | Taheri, Mohammadc | Roshanaei, Ghodratollahd | Mazdeh, Mehrdokhte | Musavi, Mehrnoosha | Hormoz, Mona Bahmania
Affiliations: [a] Faculty of Paramedicine, Research Center for Molecular Medicine, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran | [b] Research Center for Molecular Medicine, Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran | [c] Departments of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran | [d] Modeling of Noncommunicable Diseases Research Center, Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran | [e] Department of Neurology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Correspondence: [*] Corresponding author: Masoud Sabouri Ghannad, Research Center for Molecular Medicine, Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Post code: 6517838736, Iran. Tel.: +98 8138380160; Fax: +98 8138380208; E-mail:sabouri@umsha.ac.ir
Abstract: OBJECTIVES: Multiple sclerosis (MS) is a complicated disease which occurs due to relationship between genes and environmental factors that causes tissue damage by autoimmune mechanisms.We investigated and illustrated the hypotheses correlated to the evidence of several putative environmental risk factors for MS onset and progression in this part of Iran. MATERIALS AND METHODS: Univariate logistic regression was used to detect the effects of environmental factors on the risk of MS. Data were analyzed using SPSS version 16. RESULTS: The childhood history of patients with rubella, measles and chickenpox increased the risk of MS significantly. Moreover, low consumption of dairy products, avoidance of seafood consumption, cigarette smoking and exposure to tobacco smoke, stress, anxiety disorders, depress and disturbing thoughts, negative and disturbing thoughts, developing a sudden shock upon hearing bad news, having obsessive-compulsive and being depressed increased the risk of MS significantly. CONCLUSIONS: The results of the current research partially solved the puzzling question of complex interplay between environmental factors and MS disease in this part of Iran. Incorporating these factors enables more powerful and accurate detection of novel risk factors with diagnostic and prognostic methods.
Keywords: Multiple sclerosis, environmental exposure, seafood, dairy products, stress disorders
DOI: 10.3233/HAB-150289
Journal: Human Antibodies, vol. 24, no. 1-2, pp. 17-23, 2016
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