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Article type: Research Article
Authors: Erhabor, O.a; * | Muhammad, Ado Dakatab | Adias, T.C.c | Ahmed, Y.d | Erhabor, T.e
Affiliations: [a] Department of Haematology, School of Medical Laboratory Science Usmanu Danfodiyo University Sokoto, Nigeria | [b] Department of Haematology, Aminu Kano Teaching Hospital, Kano State, Nigeria | [c] Federal University Otuoke Bayelsa State, Nigeria | [d] Department of Obstetrics and Gynaecology, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria | [e] Medical Laboratory Science Council of Nigeria, Nigeria
Correspondence: [*] Corresponding author: Osaro Erhabor, Department of Haematology, School of Medical Laboratory Science Usmanu Danfodiyo University Sokoto, Nigeria. E-mail: n_osaro@yahoo.com.
Abstract: BACKGROUND: Pregnancy induces a number of physiologic changes either directly or indirectly that affect the haematologic parameters. The most frequent haematologic complication associated with pregnancy is anaemia and thrombocytopenia. OBJECTIVES: The aim of this case-control study was to investigate the prevalence of anaemia and thrombocytopenia among one hundred and twenty consecutively-recruited pregnant subjects and sixty age-matched non-pregnant controls. METHOD: Socio-demographic and clinical data were obtained using a questionnaire. Three milliliters of blood were obtained from both the pregnant subjects and non-pregnant controls and distributed into EDTA and used for full blood count was determined using the fully automated Mythic 18 3-part differential haematology analyzer. RESULT: The socio-demographic distribution among the subjects showed that the age group 25–29 years had the higher number of participants 41 (34.2%) followed by 30–34 years 39 (32.5%). Distribution based on socio-demography indicated that majority of the subjects were of Hausa ethnic group 47 (78.3), had no formal or Islamic education 53 (44.2%) and predominantly housewives 74 (61.7%). Distribution based on obstetric variables indicated that majority of the subjects were multiparous 86 (71.7%), had no problem in their previous pregnancies 99 (82.5%) and are not having problem in this current pregnancy 109 (90.8%). The HBG and HCT were significantly lower among the pregnant subjects compared to controls (p= 0.05 and 0.0308) respectively. The prevalence of anaemia and thrombocytopenia among the pregnant subjects was 75% and 6.7% respectively. The prevalence of anaemia (80%) and thrombocytopenia (8.0%) was higher among pregnant women in the second trimester compared to those in the first and third trimesters. CONCLUSION: The values obtained from this research showed an increase in prevalence of anaemia and thrombocytopenia among pregnant women compared to the non-pregnant controls. It is vital to routinely monitor the indices of anaemia and thrombocytopenia among pregnant women to reduce the incidence of these diseases and of their complications.
Keywords: Anaemia, thrombocytopenia, pregnant women, Aminu Kano Teaching Hospital, Kano State, North Western Nigeria
DOI: 10.3233/HAB-190388
Journal: Human Antibodies, vol. 28, no. 1, pp. 11-19, 2020
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