Article type: Research Article
Authors: Wu, Sheng-Hui | Shu, Xiao-Ou | Chow, Wong-Ho | Xiang, Yong-Bing | Zhang, Xianglan | Cai, Qiuyin | Li, Hong-Lan | Milne, Ginger | Wen, Wanqing | Ji, Bu-Tian | Rothman, Nathaniel | Gao, Yu-Tang | Zheng, Wei | Yang, Gong
Affiliations: Division of Epidemiology, Department of Medicine,
Vanderbilt University Medical Center, Nashville, TN, USA | Division of Cancer Epidemiology and Genetics, National
Cancer Institute, NIH, DHHS, Bethesda, MD, USA | Shanghai Cancer Institute, Shanghai, China | Division of Clinical Pharmacology, Department of
Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Note: [] Corresponding author: Gong Yang, Division of Epidemiology,
Department of Medicine, Vanderbilt University Medical Center, 2525 West End
Avenue, Suite 600 (IMPH), Nashville, TN 37203-1738, USA. Tel.: +1 615 936 0748;
Fax: +1 615 936 8291; E-mail: Gong.Yang@Vanderbilt.edu
Abstract: OBJECTIVES: This study evaluated associations of various
anthropometric measures of adiposity with a panel of inflammatory and oxidative
stress markers in a relatively lean population of Chinese women. METHODS: This analysis included 1,005 Chinese women aged 40–70
years. Plasma concentrations of inflammatory and oxidative stress markers were
measured. Anthropometric measurements were taken by trained interviewers. RESULTS: Body mass index (BMI), waist circumference (WC), and
waist-to-height ratio (WHtR) were all positively and linearly associated with
the inflammatory markers, CRP, TNF-α, soluble TNF-receptor 1 (sTNF-R1),
and IL-6. A significant positive association of these measures of adiposity
with the oxidative stress marker F_2-IsoP-M, a metabolite of
F_2-IsoPs, but with not F_2-IsoPs was
found. Differences in biomarkers between extreme quartiles of anthropometric
measurements varied widely, ranging from 9.7% for sTNF-R1 to 162.0% for CRP.
For each specific biomarker, various anthropometric measurements exhibited
similar ability to explain variations in the biomarker, with the biggest
partial r^{2} (11%) observed for CRP. CONCLUSIONS: This study suggests that both general adiposity
(measured by BMI) and central adiposity (measured by WC and WHtR) are
positively and similarly associated with various markers of inflammation and
oxidative stress in relatively lean Chinese women. The metabolite
F_2-IsoP-M of F_2-IsoPs may be a better
marker of in vivo oxidative stress than its parent compounds.
Keywords: Adiposity, inflammation, oxidative stress, biomarker
DOI: 10.3233/DMA-130969
Journal: Disease Markers, vol. 34, no. 4, pp. 279-293, 2013
Received 5 February 2013
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Accepted 5 February 2013
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Published: 2013
