Affiliations: Department of Genetics, Sanjay Gandhi Post Graduate
Institute of Medical Sciences (SGPGIMS), Lucknow, India | Department of Neurology, Sanjay Gandhi Post Graduate
Institute of Medical Sciences (SGPGIMS), Lucknow, India
Note: [] Corresponding author: Dr. Balraj Mittal (Professor), Department
of Genetics, Raebareli Road, SGPGIMS, Lucknow-226014 (U P), India. Tel.: +91
522 2668004-8, Ext. 2322; Fax: +91 522 2668973; E-mail: balraj@sgpgi.ac.in / bml_pgi@yahoo.com
Abstract: We aimed to find out if the serotonin receptor
(HT102T>C) and serotonin transporter (STin 2) polymorphisms
play any role in genetic susceptibility of migraine. For the study, 217
migraine patients and 217 healthy controls (HC) were recruited and genotyping
was carried out using the Polymerase Chain Reaction and Restriction Fragment
Length polymorphism (PCR-RFLP) method. All results were Bonferroni corrected.
We could not find any significant differences in the genotype or allele
frequencies in case of HT 102 T>C polymorphism between
migraine patients and healthy controls (P value=0.224). No
significant association was seen at allele and carrier levels. Sub-grouping the
patients on the basis of gender or on basis of migraine type i.e. with or
without aura also did not show any association. Similarly, no difference in
genotype (P value=0.236), allele (P value=0.550) or carrier frequency (P value=0.771) in STin
2 VNTR polymorphism was observed between migraine patients.
However, HT 102 TC genotype was observed to interact significantly with the
STin 2.10/10 genotype in enhancing risk of migraine, both with and without
aura. In conclusion, the HT102 T>C receptor and the STin 2
VNTR transporter polymorphisms, did not individually confer any significant
risk of migraine or its clinical subtypes but the two polymorphisms appear to
synergistically influence susceptibility to migraine. Serotonin transporter (STin2 VNTR) and receptor (HT 102T>C) polymorphisms;
Migraine with aura (MA); Migraine without aura (MO); Genetic susceptibility
