Affiliations: Department of Biochemistry, Genetic Engineering and
Biotechnology Research Division, National Research Center, Dokki, Giza,
Egypt | Internal Medicine Department, Faculty of Medicine,
Alazhar University, Naser City, Cairo, Egypt
Note: [] Corresponding author: Associate Prof. Dr. Menha Swellam,
Biochemistry Department, Genetic Engineering and Biotechnology Research
Division, National Research Center, Tahrir Street, Dokki, Giza, 12622, Egypt.
Tel.: +20 23335451; Fax: +20 23370931; E-mails: menha_m_swellam@hotmail.com,
menha_m_swellam@yahoo.com
Abstract: Objectives: To study the interrelationships of adiponectin,
C-reactive protein (CRP) and fibrinogen with each other in T2DM patients with
(T2DM-C) and without complications (T2DM-NC) among healthy individuals. Design and methods: The study comprised of 120 T2DM-C, 59 T2DM-NC
patients and 40 healthy volunteers. Biochemical markers were determined in the
serum. Results: Positivity rates of CRP and fibrinogen were significantly
increased in T2DM-C as compared to T2DM-NC or controls, whereas adiponectin
showed highest level in healthy individuals. Inflammatory biomarkers were
inversely correlated with adiponectin (P< 0.01). Lipid profiles, kidney
functions and BMI, showed positive significant correlation with CRP and
fibrinogen but negative correlation with adiponectin. For better detection of
T2DM, the combined sensitivity (98.9%) and specificity (92.5%) of fibrinogen
and adiponectin was higher than the combined sensitivity and specificity of
fibrinogen and CRP or adiponectin and CRP or than that of the biomarkers
alone. Conclusion: Elevated levels of CRP and fibrinogen and reduced level
of adiponectin can be used for early diagnosis of T2DM and can predict diabetic
complications.
Keywords: Type 2 diabetes mellitus, adiponectin, c-reactive protein, fibrinogen
