Affiliations: Department of Urology and Renal Transplantation,
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar
Pradesh, India
Note: [] Corresponding author: Dr. Rama Devi Mittal, Additional
Professor (Biochemistry), Department of Urology, SGPGIMS, Raebareli Road,
Lucknow-226014, India. Tel.: +91 522 2668004 8, Ext. 2116; Fax: +91 522
2668017; E-mails: ramamittal@yahoo.com; rmittal@sgpgi.ac.in
Abstract: Glutathione S-transferases (GSTs) play an important role in
detoxification of various toxic compounds like carcinogens in cigarette smoke
and tobacco by conjugating to toxic compounds and inactivating their hazardous
effect. Variation in Glutathione S-Transferases (GSTs) genes may alter the
catalytic efficiency of GST isoenzymes leading to potential increase in cancer
susceptibility due to various carcinogens. We therefore, investigated
association of GSTM1, GSTM3 and GSTT1 variants with
susceptibility to benign prostate hyperplasia (BPH) and cigarette, tobacco
chewing and alcohol consumption as confounding factors in 141 BPH and 184
healthy controls. Results showed increased risk for BPH susceptibility in
patients with GSTM1 null genotype (OR-2.03, p = 0.013)
and smoking (OR-3.12, p = 0.028), tobacco chewing (OR-2.54,
p = 0.039) and alcohol habits (OR-3.39, p =
0.010). Null genotype of GSTM1 with cigarette, tobacco and alcohol habits
predisposed increased risk for BPH.
