Claudin proteins in ovarian cancer

Issue title: BIOMARKERS IN OVARIAN DISEASE

Article type: Research Article

Authors: Morin, Patrice J.

Affiliations: Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Tel.: +1 410 558 8506; Fax: +1 410 558 8386; E-mail: Morinp@grc.nia.nih.gov

Abstract: Members of the claudin family of tight junction proteins have been found altered in several malignancies, including ovarian cancer. Because claudin-3 and -4 are elevated in the vast majority of ovarian tumors, they may represent useful biomarkers for detection and prognosis, as well as ideal targets for therapy using the Clostridium perfringens enterotoxin.

Journal: Disease Markers, vol. 23, no. 5-6, pp. 453-457, 2007