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Article type: Research Article
Authors: Mahmoud, Moushira A. | Mohamed, Roshdy W. | Attia, Fadia M. | Atwa, Mona A. | Abdel-moneim, Samir M.
Affiliations: Departments of Biochemistry, Suez Canal University, Ismailia, Egypt | Dermatology and Andrology, Suez Canal University, Ismailia, Egypt | Clinical Pathology, Suez Canal University, Ismailia, Egypt
Note: [] Corresponding author: Moushira Abdel-Wahab Mahmoud, Department of Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. Tel.: +20 10 3179695; Fax: +20 64 3216496; E-mail: moushiraa@yahoo.com
Abstract: Background: Little information is known about telomerase expression in the chronic benign hyperproliferative skin disease, psoriasis. Further studies are still required to investigate its usefulness as a biomarker of this skin disorder. Aim: To investigate the expression of human telomerase reverse transcriptase (hTERT) in psoriatic lesional skin and its relation to disease severity. Methods: The levels of hTERT-mRNA were quantified using real time RT-PCR in lesional versus nonlesional skin specimens from 24 psoriatic patients. Results: The expression of hTERT was detected in 16 psoriatic lesional specimens (66.7%), but in none of the normal skin. There was no relation between hTERT expression level and age of the patient or the duration of the disease. Among hTERT-positive patients, a significant positive correlation was observed between hTERT-mRNA levels and both the Psoriasis Area-and-Severity Index (PASI) and scaling scores (p=0.012 & p=0.006, respectively). Conclusion: Telomerase mRNA is detectable in lesional skin of most psoriatic patients and correlates with the severity of the disease and the rate of epidermal proliferation.
Keywords: Human telomerase reverse transcriptase, psoriasis, PASI score, scaling score
Journal: Disease Markers, vol. 22, no. 4, pp. 265-269, 2006
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