Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Nasti, Sabina | Spallarossa, Paolo | Altieri, Paola | Garibaldi, Silvano | Fabbi, Patrizia | Polito, Luisa | Bacino, Luca | Brunelli, Michele | Brunelli, Claudio | Barsotti, Antonio | Ghigliotti, Giorgio
Affiliations: Department of Internal Medicine, Cardiology and Laboratory of Cardiovascular Biology, Genova University School of Medicine, Genova, Italy
Note: [] Corresponding author: Giorgio Ghigliotti, M.D., Research Associate of Cardiology, Department of Internal Medicine, Cardiology – Genova University School of Medicine, Viale Benedetto XV, 6. 16132-Genova Italy. Tel.: +39 010 3537934; Fax: +39 010 3538638; E-mail: gghiglio@cardio.dimi.unige.it
Abstract: Background: specific polymorphisms of genes regulating intracellular redox balance and oxidative stress are related to atherogenesis. Some studies have identified a relationship between progression of atherosclerosis and C242T mutation in CYBA gene coding for p22^{phox}, a subunit of the NADH/NADPH oxidase system. Design: we investigated whether the C242T nucleotide transition is associated with the presence of coronary artery disease (CAD) in a population of 494 Caucasian Italians undergoing coronary angiography to diagnose the cause of chest pain. Results: the frequency of the T mutant allele that we found in 276 patients with angiographically documented CAD was significantly higher compared to what we observed in 218 subjects with normal coronary arteries (Controls) (respectively: 0.400 and 0.332, p<0.01). The prevalence of the T allele was even stronger when we compared: 1) early onset (age <55) vs late onset (age >65) single-vessel CAD patients (respectively: 0.75 and 0.48, p<0.05), and 2) the subgroup of CAD patients with at least one >98% stenosis in a coronary vessel vs those with no >98% stenosis in a coronary vessel (respectively: 0.425 and 0.365, p<0.05$). Conclusions: these results support the increased risk of developing early CAD and of having rapid progression of coronary stenosis in subjects carrying the C242T nucleotide transition among the Italian population.
Keywords: Oxidative stress, cardiovascular, gene, variant, NAD(P)H oxidase
Journal: Disease Markers, vol. 22, no. 3, pp. 167-173, 2006
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl