Affiliations: Department of Biochemistry, Xiangya School of
Medicine, Central South University, Changsha 410078, Hunan, China | Molecular Biology Research Center, Xiangya School of
Medicine, Central South University, Changsha 410078, Hunan, China
Note: [] Corresponding author: Han-chun Chen, MD., Ph.D., Department of
Biochemistry, Xiangya School of Medicine, Central South University, 110 Xiangya
Road, Changsha, Hunan, 410078, P.R. China. Tel.: +86 731 2650415; +86 731
4918173; Fax: +86 731 2650230; E-mail: chenhanchun@mail.csu.edu.cn
Abstract: A case-control study was conducted for analyzing the genetic
polymorphisms of phase II metabolic enzymes in 97 patients with lung cancer and
197 healthy subjects from Han ethnic group of Hunan Province located in Central
South China. The results showed that the frequencies of glutathione
S-transferase (GST) M1-null (GSTM1-) or GSTT1-null (GSTT1-) genotype alone, or
combined form of both in lung cancer patients were significantly higher than
those of the controls. Genotypes of combining GSTP1 mutant/GSTM1(-) or GSTP1
mutant/GSTT1(-) led to high risk of lung cancer. Individuals carrying any two
or all three of GSTM1(-), GSTT1(-) and GSTP1 mutant genotypes have a distinctly
increased risk of lung cancer when compared to those with GSTM1 present
(GSTM1+: GSTM1+/+ or
GSTM1+/−), GSTT1 present (GSTT1+:
GSTT1+/+ or GSTT1+/−) and GSTP1 wild
genotypes. Furthermore, individuals possessing combined genotypes of
N-acetyltransferase 2 (NAT2) rapid acetylator, GSTP1 mutant and both GSTT1(-)
and GSTM1(-) have a remarkably higher lung cancer risk than those carrying
combined NAT2 slow acetylator genotype, GSTP1 wild genotype and both
GSTT1(+) and GSTM1(+) genotypes. All
these findings suggest that the genetic polymorphisms of phase II metabolic
enzymes affect the susceptibility of lung cancer in the Han ethnic group of
Central South China.
