Affiliations: Hatch Center for MR Research, Department of Radiology,
Columbia University, New York, NY, 10032, USA | Department of Biomedical Engineering, Columbia
University, New York, NY, 10032, USA
Note: [] Corresponding author: Fernando Arias-Mendoza, MD, PhD, Hatch
Center for MR Research, Department of Radiology, Columbia University, 710 W.
168th Street, Neurological Institute Basement, New York, NY 10032, USA. Tel.:
+1 212 305 1169; Fax: +1 212 314 3557; E-mail: fa2003@columbia.edu
Abstract: Phosphorus Magnetic Resonance Spectroscopy
(^{31}P-MRS) has been utilized to study energy,
carbohydrate, and phospholipid metabolism in vitro and in vivo in
live tissues non-invasively. Despite its lack of sensitivity, its application
has extended to in situ human tissues and organs since proper signal
localization was devised. Follow-up of phosphocreatine in neuromuscular
diseases and schizophrenia and follow-up of phospholipid-related molecules in
tumors are described here to demonstrate the value of
^{31}P-MRS as an imaging technique to determine in
vivo markers of disease and in the diagnosis, prognosis, and follow-up of
human diseases.
Keywords: [TeX:] ^{31}P MR spectroscopy, chemical shift imaging, in vivo metabolism, neuromuscular disease, mitochondrial cytopathy, schizophrenia, non-Hodgkin's lymphoma, chronic lymphocytic leukemia
