Affiliations: Department of Anatomy, Physiology and Genetics, and
Institute for Molecular Medicine, Uniformed Services University School of
Medicine (USUHS), Bethesda, MD 20814, USA | Section on Molecular Genetics, Cancer Genetics Branch,
NHGRI, National Institutes of Health, Bethesda, MD 20892, USA | Veterinary Resources Program, NCRR, National
Institutes of Health, Bethesda, MD 20892, USA | Laboratory of Pathology, Hematopathology section, NCI,
NIH, Bethesda, MD 20892, USA | Institute for Pathology, University of Basel,
Switzerland | Center for Prostate Disease Research, and Department
of Surgery, Uniformed Services University School of Medicine (USUHS), Bethesda,
MD 20814, USA
Note: [] Department of Anatomy and Cell Biology, USU School of Medicine,
4301 Jones Bridge Road, Bethesda, MD 20814, USA. Tel.: +1 301 295 3204; Fax: +1
301 295 2822; E-mail: msrivastava@usuhs.mil
Abstract: The ANX7 gene codes for a Ca^{2+}-activated
GTPase, which has been implicated in both exocytotic secretion in cells and
control of growth. In this review, we summarize information regarding increased
tumor frequency in the Anx7 knockout mice, ANX7 growth suppression of human
cancer cell lines, and ANX7 expression in human tumor tissue micro-arrays. The
loss of ANX7 is significant in metastatic and hormone refractory prostate
cancer compared to benign prostatic hyperplasia. In addition, ANX7 expression
has prognostic value for predicting survival of breast cancer patients.
