Inflammatory bowel disease: Are there gender differences in the
genetics of signal transduction? A preliminary study of cytosolic low molecular
weight protein tyrosine phosphatase
Affiliations: Division of Allergology and Clinical Immunology,
University of Rome Tor Vergata School of Medicine, Rome, Italy | Division of Preventive and Social Pediatrics,
University of Rome Tor Vergata School of Medicine, Rome, Italy | Department of MCA Biology, University of Camerino
School of Science, Camerino, Italy | Division of Gastroenterology, S. Camillo Hospital,
Rome, Italy
Note: [] Prof. Pier Giulio Ronchetti died before the manuscript was
submitted. His co-authors wish to dedicate this paper to his memory
Note: [] MD, Cattedra di Allergologia ed Immunologia Clinica, Ospedale S.
Eugenio, P. le dell'Umanesimo 10, 001 Roma, Italy. Tel.: +39 6 51002451; Fax:
+39 6 51002451; E-mail:luigi.fontana@uniroma2.it
Abstract: The phenotype of cytosolic Low Molecular Weight Protein Tyrosine
Phosphatase (cLMWPTP or ACP1), an enzyme involved in signal transduction of
insulin, PDGF and T-cell receptors, has been determined in 71 patients with
Crohn's Disease (CD: 37 males and 34 females), 49 patients with Ulcerative
Colitis (UC: 27 males and 22 females) and 358 consecutive newborns (194 males
and 164 females). cLMWPTP phenotypes showing a high concentration of F isoforms
are associated with CD in females and with UC in males. Since PTPases
counteract the effects of protein tyrosines kinases, a high concentration of F
isoform of cLMWPTP may influence the mucosal response to pathogenic factors,
increasing susceptibility to CD in females and to UC in males.
Journal: Disease Markers, vol. 16, no. 3-4, pp. 163-166, 2000
