Platelet count and breast cancer stage

Article type: Research Article

Authors: Fahdrin, Andi^a | Sampepajung, Elridho^b; | Pieter, John^b | Kasim, Firdaus^c | Smaradhania, Nilam^b | Prihantono, Prihantono^b | Mariana, Nita^d | Sampepajung, Daniel^b | Faruk, Muhammad^a

Affiliations: [a] Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia | [b] Division of Oncology, Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia | [c] Department of Biostatistics, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia | [d] Division of Pediatric Surgery, Department of Surgery, Hasanuddin University, >Makassar, Indonesia

Correspondence: [*] Corresponding author: Elridho Sampepajung, Division of Oncology, Department of Surgery, Faculty of Medicine, Hasanuddin University, Jalan Perintis Kemerdekaan KM 11, Makassar 90245, Indonesia. Fax: +62411585984; E-mail: elridhosampepajung@gmail.com. ORCIDs: https://orcid.org/0000-0002-8247-0457 (P. Prihantono);  https://orcid.org/0000-0002-9236-0008 (N. Mariana);  https://orcid.org/0000-0002-7079-4585 (M. Faruk)

Abstract: INTRODUCTION:The relationship between increased platelet count and cancer classification stage has long been established. The prevalence of thrombocytosis varies from 10% to 57% in cancer patients. The pathogenesis of thrombocytosis in malignancy is uncertain. However, there is evidence that tumor cells secrete humoral factors that can cause thrombocytosis. Preoperative thrombocytosis is a poor prognostic variable in malignancies. This study investigated the correlation between platelet count and breast cancer stage. METHODS:This cross-sectional study was conducted from February 2020 to January 2021. Patient data were collected from medical records. The study population comprised breast cancer patients at Dr. Wahidin Sudirohusodo Makassar. The staging examinations were based on the tumor, node, metastasis (TNM) classification according to the American Joint Committee on Cancer (AJCC) 8th Edition. RESULTS:The study group comprised 171 breast cancer patients of varying ages. Metastasis was present in five (2.92%) patients and absent in 166 (97.8%) patients. Analyses found no statistically significant differences between the three staging groups based on the platelet count (p = 0.952). CONCLUSION:There was no statistically significant relationship between increased platelet count and staging according to the TNM classification in breast cancer patients.

Keywords: American Joint Committee on Cancer, breast cancer, platelet counts, staging

DOI: 10.3233/BD-229007

Journal: Breast Disease, vol. 41, no. 1, pp. 489-493, 2022