Breast Disease - Volume 33, issue 4

Authors: Utor, Diego Alejandro | Moreno, Pilar | Granados, M. Carmen | Reina, Rafael

Article Type: Research Article

Abstract: Mammary duct-associated inflammatory disease sequence (MDAIDS) is a common pathology in the female breast that stands out because of its high therapeutic failure rate with both medical and surgical treatments. However, in males, the incidence is extremely low, although the treatment is similar. In this article, we present two new cases of MDAIDS in men, taking advantage of this extraordinary event to review the few cases reported in medical literature regarding the origin, diagnosis and treatment of this pathology.

Keywords: Breast, male, fistula, mastitis, MDAIDS

DOI: 10.3233/BD-2012-000339

Citation: Breast Disease, vol. 33, no. 4, pp. 149-157, 2012

Authors: Soliman, Amr S. | Kleer, Celina G. | Mrad, Karima | Karkouri, Mehdi | Omar, Sherif | Khaled, Hussein M. | Benider, Abdel-Latif | Ayed, Farhat Ben | Eissa, Saad S. | Eissa, Mohab S. | McSpadden, Erin J. | Lo, An-Chi | Toy, Kathy | Kantor, Elizabeth D. | Xiao, Quin | Hampton, Claire | Merajver, Sofia D.

Article Type: Research Article

Abstract: Understanding molecular characteristics that distinguish inflammatory breast cancer (IBC) from non-IBC is crucial for elucidating breast cancer etiology and management. We included 3 sets of patients from Egypt (48 IBC and 64 non-IBC), Tunisia (24 IBC and 40 non-IBC), and Morocco (42 IBC and 41 non-IBC). Egyptian IBC patients had the highest combined erythema, edema, peau d'orange, and metastasis among the 3 IBC groups. Egyptian IBC tumors had the highest RhoC expression than Tunisians and Moroccan IBCs (87% vs. 50%, vs. 38.1, for the 3 countries, respectively). Tumor emboli were more frequent in Egyptian IBC than non-IBC (Mean ± SD: …14.1 ± 14.0 vs. 7.0 ± 12.9, respectively) (P < 0.001) and Tunisians (Mean ± SD: 3.4 ± 2.5 vs. 1.9 ± 2.0, respectively) (P < 0.01). There was no difference of emboli in Moroccan tumors (1.7 ± 1.2 vs. 1.8 ± 1.2 for IBC and non-IBC, respectively (P=0.66). This study illustrates that RhoC overexpression and tumor emboli are more frequent in IBC relative to non-IBC from Egypt and Tunisia. Tumors of Moroccans were significantly different from Egyptian and Tunisian tumors for RhoC expression and emboli. Future studies should focus on relating epidemiologic factors and clinical pictures to molecular features of IBC in these and other populations. Show more

Keywords: Inflammatory breast cancer, tumor emboli, RhoC, Egypt, Tunisia, Morocco, North Africa

DOI: 10.3233/BD-2012-000337

Citation: Breast Disease, vol. 33, no. 4, pp. 159-169, 2012

Authors: Dragoumis, Dimitrios M. | Kyropoulou, Aikaterini N. | Desiris, Klearchos I. | Assimaki, Anthoula S. | Tsiftsoglou, Aris P.

Article Type: Case Report

Abstract: Extramedullary relapses of acute lymphoblastic leukemia (ALL) are rare and usually localized in the central nervous system. We describe such an uncommon case of extramedullary relapse of ALL in the breast of a 44 year old female. The patient, who had been diagnosed with precursor B cell, Philadelphia positive (Ph+) acute lymphoblastic leukemia (ALL) 5 years before and had been in complete molecular remission for the last 19 months, was admitted to the hospital for investigation of a hard, non-tender lump in her right breast. Mammography detected a dense, ill-defined mass, whereas on grey-scale and power Doppler sonography, the appearance …of the lesion was consistent with malignancy. Histopathologic and immunohistochemical examination of the specimen demonstrated a similar immunophenotype (CD20+, CD10+, Tdt+, CD3-) as this of the onset ALL cell population in the bone marrow. Show more

Keywords: Breast, acute lymphoblastic leukemia, Philadelphia chromosome, extramedullary relapse

DOI: 10.3233/BD-2012-000340

Citation: Breast Disease, vol. 33, no. 4, pp. 171-176, 2012

Authors: Meggiorini, M.L. | Vitolo, D. | Russo, A. | Trinchieri, V. | De Felice, C.

Article Type: Research Article

Abstract: Breast tuberculosis is a rare disease in highly endemic countries, and it is even rarer in Western countries, where only occasionally the local population is affected. The rarity of the disease and particularly the lack of a typical clinical-radiological presentation may cause tuberculosis to be mistaken for breast cancer or a pyogenic abscess. The authors present a case of breast tuberculosis in a 27-year-old nulliparous woman, an Italian citizen of the Caucasian race, who has never resided in a tuberculosis endemic area. She presented with painful retroareolar and para-areolar swelling in the right breast associated with cutaneous hyperemia (without fistulization), …resistant to antibiotic therapy. Histopathological examination revealed features of mastitis with epithelioid histiocytes and Langhans giant cells and was characterized by the presence of caseous necrosis which suggested tuberculous inflammation. Ziehl-Neelsen staining showed the presence of acid fast bacilli. In countries where tuberculosis is non-endemic, breast tuberculosis should always be included in the differential diagnosis in cases of inflammatory breast lesions resistant to the usual antibiotic therapies. Early recognition may prevent both clinical progression and surgical excision, as breast tuberculosis usually regresses as a response to appropriate anti-tuberculosis therapy. Show more

Keywords: Breast tuberculosis, Caucasian Italian woman

DOI: 10.3233/BD-2012-000338

Citation: Breast Disease, vol. 33, no. 4, pp. 177-182, 2012

Authors: Saied, Abdul | Bhati, Chandra | Sharma, Ranjna | Garrean, Sean | Salti, George

Article Type: Research Article

Abstract: Small bowel obstruction from luminal gastrointestinal metastasis is a rare, but recognized, presentation of metastatic breast cancer. Herein, we report a case of a small bowel obstruction from lobular breast cancer metastasis to the terminal ileum, occurring over a decade after diagnosis and treatment of the initial primary cancer. Our review highlights the presentation and management of this unusual disease manifestation, including diagnosis of the gastrointestinal process, identification of the primary cancer, surgical treatment of the abdominal pathology, systemic therapy for metastatic disease, and survival data for patients with this disease process.

DOI: 10.3233/BD-2010-0311

Citation: Breast Disease, vol. 33, no. 4, pp. 183-188, 2012

Authors: Patterson, Jonathan D. | Wilson, Jonathan E. | Dim, Daniel | Talboy, Glenn E.

Article Type: Research Article

Abstract: Sarcomas of the breast are rare, comprising 1% of all breast tumors. Primary chondrosarcomas of the breast account for an extremely rare subset of such tumors, with few reports in the literature. We report the case of a 52 year-old woman with a primary chondrosarcoma of the breast and review the current literature.

Keywords: Breast cancer, sarcoma, chondrosarcoma

DOI: 10.3233/BD-2009-0303

Citation: Breast Disease, vol. 33, no. 4, pp. 189-191, 2012

Article Type: Other

DOI: 10.3233/BD-2012-33407

Citation: Breast Disease, vol. 33, no. 4, pp. 193-195, 2012