Affiliations: [a] Third Department of Medicine, Oncology Unit, Sotiria General Hospital, National and Kapodistrian University of Athens, Athens, Greece
Correspondence:
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Corresponding author: Georgia Gomatou, 3rd Department of Medicine, Sotiria General Hospital, Messogion Ave 152, Athens 11527, Greece. Tel.: +30 210 7763332; Fax: 210 7778838; E-mail: georgia.gomatou@gmail.com
Abstract: Breast cancer is the main site of origin of orbital metastatic disease. Although invasive lobular breast carcinoma accounts for 10–15% of all breast cancer cases, it has been noticed that it metastasizes to the orbit more often compared to breast cancer of no special type (NST). The pathogenesis of this metastasis is not entirely understood; however, it seems that the unique tissue-specific characteristics of orbital microenvironment might contribute to metastatic disease in this particular site. Given the increasing survival of breast cancer patients and the prolonged metastatic potential of invasive lobular breast carcinoma, it is possible that the incidence of this rare metastasis might increase in the future. The purpose of this review is to present clinical manifestations, immunohistochemical characteristics and therapeutic options for orbital metastases from invasive lobular carcinoma.
Keywords: Lobular breast cancer, ILBC, Orbital/ocular metastasis
DOI: 10.3233/BD-190398
Journal: Breast Disease, vol. 38, no. 3-4, pp. 85-91, 2019
