Genetically Engineered Rat Models for Breast Cancer

Issue title: Comparative Pathobiology of Breast Cancer

Guest editors: Robert D. Cardiff

Article type: Research Article

Authors: Smits, Bart M.G. | Cotroneo, Michelle S. | Haag, Jill D. | Gould, Michael N.^{; *}

Affiliations: McArdle Lab for Cancer Research, University of Wisconsin – Madison, Madison, WI 53706, USA | Department of Pathology and Laboratory Medicine, Center for Comparative Medicine, University of California, Davis, CA 95616, USA

Correspondence: [*] Corresponding author: Dr. Michael N. Gould, McArdle Lab for Cancer Research, Rm 506A, University of Wisconsin – Madison, Madison, WI 53706, USA. Tel.: +1 608 263 6615; Fax: +1 608 262 2824; E-mail: gould@oncology.wisc.edu

Abstract: Rat mammary cancers generally resemble many features of human breast cancer. With the recent developments in rat genetic engineering, the rat has become an excellent model system to study aspects of the molecular etiology of breast cancer. In this review, we describe the efforts to generate genetically engineered rat models for breast cancer.

DOI: 10.3233/BD-2007-28106

Journal: Breast Disease, vol. 28, no. 1, pp. 53-61, 2007