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Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 2nd International Conference on Biomedical Engineering and Biotechnology, 11–13 October 2013, Wuhan, China
Article type: Research Article
Authors: Sun, Tai-Ping | Shieh, Hsiu-Li | Liu, Chun-Lin | Chen, Chung-Yuan;
Affiliations: Institute of Electrical Engineering, National Chi Nan University, Nantou, 545, Taiwan, ROC | Graduate Program of Optoelectronic Technology, National Chi Nan University, Nantou, 545, Taiwan, ROC
Note: [] Chung-Yuan Chen. E-mail: s2323905@ncnu.edu.tw.
Abstract: In this study, a urea biosensor was prepared by the immobilization of urease onto the sensitive membrane of an extended-base bipolar junction transistor. The pH variation was used to detect the concentration of urea. The SnO2/ITO glass, fabricated by sputtering SnO2 on the conductive ITO glass, was used as a pH-sensitive membrane, which was connected with a commercial bipolar junction transistor device. The gels, fabricated by the poly vinyl alcohol with pendent styrylpyridinium groups, were used to immobilize the urease. This readout circuit, fabricated in a 0.35-um CMOS 2P4M process, operated at 3.3V supply voltage. This circuit occupied an area of 1.0 mm × 0.9 mm. The dynamic range of the urea biosensor was from 1.4 to 64 mg/dl at the 10 mM phosphate buffer solution and the sensitivity of this range was about 65.8 mV/pUrea. The effect of urea biosensors with different pH values was considered, and the characteristics of urea biosensors based on EBBJT were described.
Keywords: Extended-base bipolar junction transistor, urea, SnO2, ITO, CMOS
DOI: 10.3233/BME-130779
Journal: Bio-Medical Materials and Engineering, vol. 24, no. 1, pp. 21-28, 2014
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