Hemocompatibility of Diamond-Like Carbon Coating

Article type: Research Article

Authors: Dion, I. | Roques, X.^; | Baquey, H. | Baudet, E. | Basse Cathalinat, B. | More, N.

Affiliations: INSERM U.306 et Laboratoire de Biophysique, Universite Bordeaux II 146, rue Leo Saignat, 33076 Bordeaux Cedex, France | Service de Chirurgie Cardiovasculaire, Hopital Cardiologique du Haut-Leveque, Avenue de Magellan, 33604 Pessac Cedex, France

Abstract: The new prosthetic heart valve that has been designed by FII Company and Pr. Baudet involves a new “composite” material: titanium alloy T16A14V coated with Diamond-like Carbon. The purpose of this study was to evaluate the in vitro hemocompatibility of this new material in terms of protein adsorption and platelet retention. The static protein adsorption test gave interesting results, particularly for the albumin assay (237%) compared to the results obtained with a silicone elastomer chosen as a reference; the fibrinogen quantity, adsorbed on the surface of the material was slightly higher than that adsorbed on the silicone surface. Platelets adhere quite twice as much as they do on the reference surface. Such investigations showed good hemocompatibility results and should initiate further studies.

Keywords: diamond-like carbon, hemocompatibility, heart valves, biomaterials

DOI: 10.3233/BME-1993-3106

Journal: Bio-Medical Materials and Engineering, vol. 3, no. 1, pp. 51-55, 1993