Synthesis and characterization of Bioglass-based bone grafts with Gelatine substitution for biomedical applications

Article type: Research Article

Authors: Aksakal, B.^{a; b; *} | Demirel, M.^c

Affiliations: [a] Dept Metallurgy and Mater Eng, Faculty of Chemical and Metallurgy, Yildiz Technical University, Istanbul, Turkey. E-mail: baksakal@yildiz.edu.tr | [b] Dept of Mech Eng, Engineering Faculty, Munzur University, Tunceli, Turkey. E-mail: baksakal2@gmail.com | [c] Vocational School of Technical Sci, Adiyaman University, Adiyaman, Turkey. E-mail: mdemirel@adiyaman.edu.tr

Correspondence: [*] Corresponding author. E-mails: baksakal@yildiz.edu.tr, baksakal2@gmail.com.

Abstract: Background:Syntesizing alternative bone graft materials are important in biomedical applications. Their morphology, mechanical properties and cell viability plays an important role in tissue engineering. Objective:Bioglass (B) based bone grafts with Gelatin (G) substitution were syntesized via the sol-gel method and were compared with various Gelatin and Bioglass concentrations (wt%). Methods:Syntesized bone grafts were characterized by Scanning Electron Microscopy (SEM) and X-ray diffraction (XRD) to show the structural and morphological changes of the fabricated B-based bone grafts. Results:It was demonstrated that the concentration of pore size increased with increasing amounts of Gelatin in wt%. The biograft-B40G20 produced the highest flexture strength and hardness. Increasing the pore size caused a decrease in hardness and flexture stress of B-based biografts. Conclusions:Cell viability tests were conducted on the fabricated biografts and it was shown that the cell viability increased in fabricated B-based bone grafts.

Keywords: Bioglass, sol gel, mechanical properties, cell viability

DOI: 10.3233/BME-171664

Journal: Bio-Medical Materials and Engineering, vol. 28, no. 2, pp. 159-168, 2017