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Article type: Research Article
Authors: Gnedenkov, Sergey V.a | Sinebryukhov, Sergey L.a | Puz′, Artyom V.a | Egorkin, Vladimir S.a; * | Kostiv, Roman E.b
Affiliations: [a] Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159, Prosp. 100-letiya Vladivostoka, Vladivostok 690022, Russia | [b] Pacific State Medical University, 2, Prosp. Ostryakova, Vladivostok, Russia
Correspondence: [*] Corresponding author. Tel.: +7-902-5562027; E-mail: egorkin@ich.dvo.ru.
Abstract: The method of formation of bioactive calcium-phosphate coating on medical titanium alloy Ti–6Al–4V (3.5–5.3% V; 5.3–6.8% Al; balance –Ti) by plasma electrolytic oxidation (PEO) has been developed. Evaluation of osteogenerating properties of the coating at fractures of the shaft of the femur on Wistar line laboratory rats has been performed. It has been established that the calcium-phosphate PEO coating accelerates osteogenesis and promotes the formation of a pronounced periosteal callus in the fracture area. The presence of calcium phosphates in the PEO coating surface layer significantly accelerates the growth of bone tissue on the titanium surface.
Keywords: Calcium-phosphate coatings, titanium alloy Ti–6Al–4V, plasma electrolytic oxidation, implant, osteogenesis
DOI: 10.3233/BME-161608
Journal: Bio-Medical Materials and Engineering, vol. 27, no. 6, pp. 551-560, 2016
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