Nanostructured thick 3D nanofibrous scaffold can induce bone

Issue title: Selected Papers from the 5th China–France International Symposium “Stem Cells: From Bench to Bedside”, 12–14 December 2013, Kunming, China

Article type: Research Article

Authors: Eap, Sandy | Morand, David^; | Clauss, François^; | Huck, Olivier^; | Stoltz, Jean-François | Lutz, Jean-Christophe^; | Gottenberg, Jacques-Eric | Benkirane-Jessel, Nadia^{; ;} | Keller, Laetitia | Fioretti, Florence^;

Affiliations: French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Faculté de Médecine, Strasbourg, France | Université de Strasbourg, Faculté de Chirurgie Dentaire, Strasbourg, France | Hôpital Civil, service de Chirurgie Maxillo-Faciale, Strasbourg, France | Hôpital Central, Service de Chirurgie Orthopédique and CNRS UMR 7561, Nancy, France

Note: [] Address for correspondence: Dr. Nadia Benkirane-Jessel, Osteoarticular & Dental Regenerative Nanomedicine, UMR 1109, INSERM/Université de Strasbourg, Faculté de Médecine, 11 rue Humann, 67 085 Strasbourg, France. E-mail: nadia.jessel@inserm.fr

Abstract: Designing unique nanostructured biomimetic materials is a new challenge in modern regenerative medicine. In order to develop functional substitutes for damaged organs or tissues, several methods have been used to create implants able to regenerate robust and durable bone. Electrospinning produces nonwoven scaffolds based on polymer nanofibers mimicking the fibrillar organization of bone extracellular matrix. Here, we describe a biomimetic 3D thick nanofibrous scaffold obtained by electrospinning of the biodegradable, bioresorbable and FDA-approved polymer, poly(ε-caprolactone). Such scaffold presents a thickness reaching one centimeter. We report here the demonstration that the designed nanostructured implant is able to induce in vivo bone regeneration.

Keywords: Bone induction, tissue engineering, 3D scaffold, polycaprolactone, electrospinning

DOI: 10.3233/BME-141248

Journal: Bio-Medical Materials and Engineering, vol. 25, no. s1, pp. 79-85, 2015