Issue title: Selected Papers from the 5th China–France International Symposium “Stem Cells: From Bench to Bedside”, 12–14 December 2013, Kunming, China
Article type: Review Article
Authors: Stoltz, J.-F.; ; ; | Bensoussan, D.; ; | Zhang, L. | Decot, V.; ; | De Isla, N.; | Li, Y.P. | Huselstein, C.; | Benkirane-Jessel, N. | Li, N. | Reppel, L.; | He, Y. | Li, Y.Y.;
Affiliations: CNRS, UMR 7365, Biopole, Faculté de Médecine, Vandœuvre-lès-Nancy, France | CHU de Nancy, Unité de Thérapie Cellulaire et Tissulaire (FR CNRS-INSERM-UHP-CHU 3209), Hôpitaux de Brabois, Vandœuvre-lès-Nancy, France | Université de Lorraine, Nancy, France | Service de Thérapie Cellulaire, Calmette Hospital, Kunming, China | Medical College and Zhongnan Hospital, Wuhan University, China | INSERM UMR 1109, Faculté de Médecine, Strasbourg, France | Anzhen Hospital, Cardiovascular and Lung Research Center, Beijing, China
Note: [] Address for correspondence: Prof. Jean-François Stoltz, CHU de Nancy, Unité de Thérapie Cellulaire et Tissus (UTCT), Hôpitaux de Brabois, rue du Morvan, 54511 Vandœuvre-lès-Nancy, France. E-mail: jf.stoltz@chu-nancy.fr
Abstract: Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin, there has been increasing interest in the study of undifferentiated progenitors that have ability to proliferate and differentiate in different tissues. Different stem cells (SC) with different potential can be isolated and characterised. Despite the promise of embryonic stem cells, in many cases, adult stem cells provide a more interesting approach to clinical applications. It is undeniable that mesenchymal stem cells (MSC) from bone marrow, adipose tissue or MSC of Wharton Jelly, which have limited potential, are of interest for clinical applications in regenerative medicine because they are easily separated and prepared and no ethical problems are involved in their use. During the last 10 years, these multipotent cells have generated considerable interest and in particular have been shown to escape allogeneic immune response and be capable of immunomodulatory activity. These properties may be of a great interest for regenerative medicine. Different clinical applications are under study (cardiac insufficiency, atherosclerosis, stroke, bone, cartilage, diabetes, ophthalmology, urology, liver, organ's reconstruction…).
Keywords: Stem cells, tissue engineering, clinical studies, international regulations, forecast markets
DOI: 10.3233/BME-141225
Journal: Bio-Medical Materials and Engineering, vol. 25, no. s1, pp. 3-26, 2015
