Technology and Health Care - Volume 26, issue 5

Authors: Cho, Myoung-Ock | Kim, Subin | Lee, Ji Yeon | Oh, Jong Hyun | Kim, Jee Young | Bong, Sung Rok | Chung, Chanil | Kim, Jung Kyung

Article Type: Other

Abstract: BACKGROUND: Although AIDS-related mortality has declined since the introduction of antiretroviral therapy (ART), HIV/ AIDS patients are predominantly present in developing countries that lack high-cost diagnostic devices and human expertise. OBJECTIVE: New methods for counting CD4+ cells cost-effectively are needed to replace conventional flow cytometry-based diagnosis. METHODS: We developed a CD4+ cell analyzer, ADAMII, which is a benchtop fluorescence image-based CD3+/4+ cell counting analyzer. It bears a three-channel light source and performs CD3+/4+ counting assays. The automatic 3D stage captures a maximum of 136 images that are subsequently processed and analyzed using a software …integrated into the system. RESULTS: Results obtained using ADAMII were compared with data obtained by conventional methods using a FACSCalibur flow cytometer and the point-of-care PIMA CD4 analyzer. Both comparisons between ADAMII vs. FACS and ADAMII vs. PIMA data yielded a strong correlation with an R 2 value of 0.98, which ensures the feasibility of CD4 test by ADAMII. CONCLUSIONS: The proposed method using ADAMII can be easily employed in resource-limited areas to replace conventional flow cytometers, which are expensive and require highly trained staff. Show more

Keywords: CD4+ cells, HIV, AIDS, point-of-care, cell analyzer, image cytometry

DOI: 10.3233/THC-181354

Citation: Technology and Health Care, vol. 26, no. 5, pp. 867-871, 2018

Authors: Shin, Sun-Shil | Shin, Gyu-Cheol | Kim, Do-Hee | Sim, Hyo-Min | Jeong, Jin-Gyeong | Yoo, Won-Gyu

Article Type: Other

Abstract: BACKGROUND: The orientation of the pelvis is of particular importance to the sagittal curve of the spine and has geometric relationships with the top of the spine and lumbar lordosis. Changes in spinal shape or disruptions of sagittal balance in the spine, such as a flattened lumbar spine, have significant negative effects. OBJECTIVE: The aim of this study was to investigate the effects of the posterior superior iliac spine support device (PSD) on upper trunk acceleration during gait in individuals with flat lumbar back posture. METHODS: In total, 10 young male subjects with reduced …lumbar lordosis (global lumbar lordosis angle (T10–S2): < - 20 ∘ ) were recruited for this study. Participants walked 7 m with and without wearing a PSD at a self-selected speed while fitted with an accelerometer attached over the T7 spinous process. RESULTS: The normalized AP acceleration of T7 with PSD (40.57 ± 11.22%) was significantly higher than those without PSD (37.10 ± 10.46%, p = 0.035). CONCLUSIONS: We found that wearing the PSD immediately improved pelvic physiological movement during walking in individuals with lumbar flat back posture. Our findings may help healthcare professionals manage flat back posture in asymptomatic younger individuals. Show more

Keywords: Flat lumbar back posture, posterior superior iliac spine support device, pelvic movement, upper trunk acceleration

DOI: 10.3233/THC-181466

Citation: Technology and Health Care, vol. 26, no. 5, pp. 873-878, 2018