Journal of Pediatric Rehabilitation Medicine - Volume 5, issue 3

Authors: Kurowski, Brad | Martin, Lisa J. | Wade, Shari L.

Article Type: Research Article

Abstract: Human genetic association studies in individuals with traumatic brain injury (TBI) have increased rapidly over the past few years. Recently, several review articles evaluated the association of genetics with outcomes after TBI. However, almost all of the articles discussed in these reviews focused on adult TBI. The primary objective of this review is to gain a better understanding of which genes and/or genetic polymorphisms have been evaluated in pediatric TBI. Our initial search identified 113 articles. …After review of these articles only 5 genetic association studies specific to pediatric TBI were identified. All five of these studies evaluated the apolipoprotein (APOE) gene. The study design and methods of these identified papers will be discussed. An additional search was then performed to evaluate genes beyond APOE that have been evaluated in adult TBI; findings from these studies are highlighted. Larger genetic studies will need to be performed in the future to better elucidate the association of APOE and other genes with outcomes after TBI in children. There is great potential to utilized genetic information to inform prognosis and management after TBI in children; however, we have much work ahead of us to reach the goal of individualized management. Show more

Keywords: Brain injuries, child, genes, genetic polymorphism, epidemiology, pediatric, humans

DOI: 10.3233/PRM-2012-0214

Citation: Journal of Pediatric Rehabilitation Medicine, vol. 5, no. 3, pp. 217-231, 2012

Authors: Yap, Jennifer L. | Wachtel, Lee E. | Ahn, Edward S. | Sanz, Jacqueline H. | Slomine, Beth S. | Pidcock, Frank S.

Article Type: Research Article

Abstract: This report describes a patient who developed agitation, disorientation, visual hallucinations, inappropriate verbal outbursts, and impaired memory following resection of a choroid plexus papilloma. No medical, neurologic, or metabolic disorders unrelated to the surgery were identified. Five weeks following surgery, treatment with aripiprazole, a partial dopamine agonist, was started to address the delirious state. Improvements in agitation, orientation, memory, and executive functions, as well as a decrease in emotional lability, began within …twenty-four hours and continued over the remainder of the inpatient hospitalization. Five months after initial resection, aripiprazole was discontinued without worsening of cognitive or emotional functions. Persistent difficulties with working memory, planning, judgment, and visuospatial skills were noted on neuropsychological examination six months following tumor removal. This case illustrated the therapeutic benefit of aripiprazole for treatment of mental status changes associated with resection of a posterior fossa tumor. Show more

Keywords: Aripirazole, cerebellar affective syndrome, posterior fossa syndrome, cerebellar tumor

DOI: 10.3233/PRM-2012-0215

Citation: Journal of Pediatric Rehabilitation Medicine, vol. 5, no. 3, pp. 233-238, 2012

Article Type: Other

DOI: 10.3233/PRM-2012-0216

Citation: Journal of Pediatric Rehabilitation Medicine, vol. 5, no. 3, pp. 239-240, 2012

Article Type: Research Article

DOI: 10.3233/PRM-2012-0217

Citation: Journal of Pediatric Rehabilitation Medicine, vol. 5, no. 3, pp. 241-242, 2012