Journal of Alzheimer's Disease - Volume 48, issue 2

Authors: El Haj, Mohamad | Gély-Nargeot, Marie-Christine | Raffard, Stéphane

Article Type: Research Article

Abstract: Destination memory, or the ability to remember the destination to whom a piece of information was addressed, is found to be compromised in Alzheimer’s disease (AD). Our paper investigated the relationship between destination memory and theory of mind in AD since both destination memory and theory of mind are social abilities that require processing attributes of interlocutors. Mild AD participants and controls were administered tasks tapping destination memory, affective theory of mind, and 1st and 2nd order cognitive theory of mind. Relative to controls, AD participants showed compromise in destination memory and 2nd order cognitive theory of mind, but preserved …performance on affective and 1st order cognitive theory of mind. Significant correlations were observed between destination memory, and 1st and 2nd order cognitive theory of mind in AD participants and controls. By demonstrating a relationship between compromises in 2nd order theory of mind and in destination memory, our work highlights links between social cognition and memory functioning in AD. Show more

Keywords: Alzheimer’s disease, destination memory, episodic memory, social cognition, theory of mind

DOI: 10.3233/JAD-150467

Citation: Journal of Alzheimer's Disease, vol. 48, no. 2, pp. 529-536, 2015

Authors: Wood, Paul L. | Medicherla, Srikanth | Sheikh, Naveen | Terry, Bradley | Phillipps, Aaron | Kaye, Jeffrey A. | Quinn, Joseph F. | Woltjer, Randall L.

Article Type: Research Article

Abstract: Previous studies have demonstrated augmented levels of diacylglycerols (DAG) in the frontal cortex and plasma of Alzheimer’s disease (AD) patients. We extended these findings from non-targeted lipidomics studies to design a lipidomics platform to interrogate DAGs and monoacylglycerols (MAG) in the frontal cortex and plasma of MCI subjects. Control subjects included both aged normal controls and controls with normal cognition, but AD pathology at autopsy, individuals termed non-demented AD neuropathology. DAGs with saturated, unsaturated, and polyunsaturated fatty acid substituents were found to be elevated in MCI frontal cortex and plasma. Tandem mass spectrometry of the DAGs did not reveal any …differences in the distributions of the fatty acid substitutions between MCI and control subjects. While triacylglycerols were not altered in MCI subjects there were increases in MAG levels both in the frontal cortex and plasma. In toto , increased levels of DAGs and MAGs appear to occur early in AD pathophysiology and require both further validation in a larger patient cohort and elucidation of the lipidomics alteration(s) that lead to the accumulation of DAGs in MCI subjects. Show more

Keywords: Alzheimer’s disease, diacylglycerols, mild cognitive impairment, monoacylglycerols

DOI: 10.3233/JAD-150336

Citation: Journal of Alzheimer's Disease, vol. 48, no. 2, pp. 537-546, 2015

Authors: Reddy, P. Hemachandra | Blackmon, Joan | Molinar-Lopez, Veronica | Ament, Clay | Manczak, Maria | Kandimalla, Ramesh | Yin, Xianglin | Pandey, Akhilesh | Kuruva, Chandra Sekhar | Wang, Rui | Fry, David | Osborn, Carrah | Stonum, Kathleen | Quesada, Kandi | Gonzales, Ruben | Boles, Annette

Article Type: Research Article

Abstract: The Garrison Institute on Aging (GIA) is an established institute within Texas Tech University Health Sciences Center, whose mission is to promote healthy aging through cutting-edge research on Alzheimer’s disease (AD) and other diseases of aging through innovative educational opportunities for students, clinicians, researchers, health care professionals, and the public. The GIA has multiple programs, including both research and education on healthy aging and AD, community outreach, caregiving, the Retired Senior Volunteer Program, Healthy Lubbock, the GIA Brain Bank, healthy aging seminars, research seminars, and collaborations and scholarships. The GIA programs connect basic and clinical researchers and health care professionals, …and provide a unique environment to help our growing elderly population and patients with AD and their families. Show more

DOI: 10.3233/JAD-150490

Citation: Journal of Alzheimer's Disease, vol. 48, no. 2, pp. 547-555, 2015

Article Type: Meeting Report

DOI: 10.3233/JAD-150604

Citation: Journal of Alzheimer's Disease, vol. 48, no. 2, pp. 557-561, 2015