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Concentrating on molecular biomarkers in cancer research, Cancer Biomarkers publishes original research findings (and reviews solicited by the editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion.
The disease markers may include, but are not limited to, genomic, epigenomic, proteomics, cellular and morphologic, and genetic factors predisposing to the disease or indicating the occurrence of the disease. Manuscripts on these factors or biomarkers, either in altered forms, abnormal concentrations or with abnormal tissue distribution leading to disease causation will be accepted.
Authors: Zhang, Yu | Wang, Ruixia | Zhu, Longbiao | Zhang, Shangyue | Yuan, Hua | Jiang, Hongbing
Article Type: Research Article
Abstract: Background: Phospholipase C epsilon 1 (PLCE1) plays crucial roles in carcinogenesis and progression of several cancers. A single nucleotide polymorphism (SNP, rs2274223) in PLCE1 has been identified as a novel susceptibility locus. Methods: To evaluate the role of the Phospholipase C epsilon 1 (PLCE1) polymorphism in cancer susceptibility. We performed a meta-analysis of all available studies, including 8,689 cases and 10,794 controls to derive a more precise relationship. An odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association between PLCE1 rs2274223 polymorphism and cancer risk. Results: A total of 14 …case-control studies were included in the present meta-analysis. Overall significant associations were observed (AG vs. AA: OR=1.17, 95%CI=1.04–1.31; GG vs. AA: OR=1.32, 95%CI=1.06–1.66; AG/GG vs. AA: OR=1.19, 95%CI=1.05–1.34; G vs. A: OR=1.16, 95%CI=1.04–1.29) in all cancer types. In the subgroup analysis, PLCE1 rs2274223 polymorphism was significantly increased risk of cancer in Chinese population by ethnicity and upper aerodigestive tract cancer by cancer types. Conclusions: Our meta-analysis suggested the PLCE1 rs2274223 might act as a cancer risk factor among all subjects, especially in the Chinese population and upper aerodigestive tract cancer. Show more
Keywords: Meta-analysis, polymorphism, cancer, PLCE1, rs2274223
DOI: 10.3233/CBM-130388
Citation: Cancer Biomarkers, vol. 13, no. 6, pp. 483-489, 2013
Article Type: Other
DOI: 10.3233/CBM-2013-13612
Citation: Cancer Biomarkers, vol. 13, no. 6, pp. 491-496, 2013
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