Affiliations: [a] Department of Pharmacy, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi, China | [b] Guilin Medical University, Guilin, Guangxi, China
Correspondence:
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Corresponding authors: Xuefeng Wu and Guangyi Meng, Department of Pharmacy, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi, China. E-mails: wuxuef2009@126.com, gxmu-mgy@163.com.
Abstract: BACKGROUND: How to comprehensively evaluate the rationality of drug use is a challenging issue. OBJECTIVE: To establish the evaluation index of the effective use of tislelizumab, so as to ensure its higher rationality and normalization in clinical application. METHODS: Based on the indications, drug instructions, and relevant guidelines of the National Basic Medical Insurance Restriction Catalogue, a retrospective analysis and evaluation of 286 cases of using tislelizumab injection in our hospital from January to December 2022 were conducted using the weighted technique for order of preference by similarity to ideal solution (TOPSIS) method. RESULTS: Among the 286 medical records evaluated, the main irrational manifestations were inappropriate indications (90 cases, 31.47%), auxiliary examination and laboratory examination did not meet the minimum requirements of combination chemotherapy drugs (40 cases, 13.99%), the drug course was not standard (39 cases, 13.64%). Among the included cases, 57.34% were reasonable cases (Ci⩾ 0.8), 10.84% were basic reasonable cases (0.6 ⩽Ci< 0.8), and 31.82% were unreasonable cases (Ci< 0.6). CONCLUSION: The TOPSIS method, with its attribute hierarchical model (AHM)-weighted approach, can be employed as the rational assessment technique for the injection of tislelizumab. The clinical application of tislelizumab in our hospital is still insufficient, which needs to be further improved management.
Keywords: Drug use evaluation, weighted TOPSIS, Tislelizumab, attribute hierarchical model
