Affiliations: School of Computer Science and Engineering, Northeastern University, Shenyang, Liaoning, China
Correspondence:
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Corresponding author: Shuaizong Si, School of Computer Science and Engineering, Northeastern University, NO. 195 Chuangxin Road Hunnan District, Shenyang, Liaoning 110169, China. E-mail: bin.wang.brilliant@gmail.com.
Abstract: BACKGROUND: Pulmonary nodule detection can significantly influence the early diagnosis of lung cancer while is confused by false positives. OBJECTIVE:In this study, we focus on the false positive reduction and present a method for accurate and rapid detection of pulmonary nodule from suspective regions with 3D texture and edge feature. METHODS:This work mainly consists of four modules. Firstly, small pulmonary nodule candidates are preprocessed by a reconstruction approach for enhancing 3D image feature. Secondly, a texture feature descriptor is proposed, named cross-scale local binary patterns (CS-LBP), to extract spatial texture information. Thirdly, we design a 3D edge feature descriptor named orthogonal edge orientation histogram (ORT-EOH) to obtain spatial edge information. Finally, hierarchical support vector machines (H-SVMs) is used to classify suspective regions as either nodules or non-nodules with joint CS-LBP and ORT-EOH feature vector. RESULTS:For the solitary solid nodule, ground-glass opacity, juxta-vascular nodule and juxta-pleural nodule, average sensitivity, average specificity and average accuracy of our method are 95.69%, 96.95% and 96.04%, respectively. The elapsed time in training and testing stage are 321.76 s and 5.69 s. CONCLUSIONS:Our proposed method has the best performance compared with other state-of-the-art methods and is shown the improved precision of pulmonary nodule detection with computationaly low cost.
Keywords: 3D pulmonary nodule detection, small pulmonary nodule reconstruction, local binary patterns (LBP), edge orientation histogram (EOH), H-SVM classifier, CT image database
