Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Wang, Fanga | Qiao, Wub | Xu, Xiaochenc | Wang, Shujund | Regenstein, Joe M.e | Bao, Binb; f; * | Ma, Mingb; f; *
Affiliations: [a] Shanghai University of Medicine and Health Sciences, Shanghai 201318, China | [b] College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China | [c] Shanghai MAXAM Company Limited, Shanghai 200333, China | [d] Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Huaihai Institute of Technology, Lianyungang 222005, Jiangsu, China | [e] Department of Food Science, Cornell University, Ithaca 14853-7201, NY, USA | [f] Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), Ministry of Agriculture, Shanghai 201306, China
Correspondence: [*] Corresponding authors: Bin Bao and Ming Ma, College of Food Science and Technology, Shanghai Ocean University, No. 999 Hucheng Ring Road, Pudong New Area, Shanghai 201306, China. Tel./Fax: +86 021 6190 0388; E-mail: bbao@shou.edu.cn, mma@shou.edu.cn.
Abstract: BACKGROUND: Periodontitis is a chronic inflammatory disease caused by Porphyromonas gingivalis that leads to a series of periodontal tissue injuries. Egg yolk immunoglobulins (IgY) is procuded in egg yolk and inhibits P. gingivalis. OBJECTIVE: The aim was to evaluate the effect of IgY on experimental periodontitis caused by P. gingivalis. METHODS: The second molars of rats were ligatured using medical 5-0 silk and smeared with P. gingivalis to induce experimental periodontitis. Then, the rats were smeared with 2 mL IgY solutions or 0.9% NaCl in the oral cavity for up to 4 wk. The scores for gingival index, plaque index and probe on bleeding, the levels of IL-6 and TNF-α, X-ray radiography and histology were used to determine the efficacy of the IgY on experimental periodontitis. RESULTS: The clinical indices improved; the levels of IL-6 and TNF-α were significantly (p< 0.05) decreased; the X-rays and histomorphological observations suggested that the periodontal inflammation and periodontitis were alleviated compared to the control. CONCLUSIONS: IgY showed significant effects on anti-inflammatory, anti-coaggregation activity, and protected against alveolar bone loss. Therefore, it had a beneficial effect on preventing experimental periodontitis caused by P. gingivalis.
Keywords: Periodontitis, egg yolk immunoglobulins, IgY, Porphyromonas gingivalis, IL-6, TNF-α
DOI: 10.3233/THC-181255
Journal: Technology and Health Care, vol. 26, no. 5, pp. 805-814, 2018
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl