Affiliations: Section of Experimental Anaesthesiology, Department of Anaesthesiology and Critical Care Medicine, University of Freiburg, Germany
Correspondence:
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Corresponding author: Volker Kessler (Res. Eng.), Section of Experimental Anaesthesiology, Department of Anaesthesiology and Critical Care Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany. Tel.: +49 761 270 2329; Fax: +49 761 270 2396; E-mail: kessler@ana1.ukl.uni-freiburg.de.
Abstract: For analysis of respiratory system mechanics the very complex structure of the respiratory system is strongly simplified to a simple resistance-compliance-model. While for most patients this simplification seems sufficient, in patients with pulmonary disease this model is inappropriate. Additionally, to regional inhomogeneity throughout the lung, large volume accelerations due to the strongly decreased respiratory system compliance together with a mass increase of the patients’ lungs, i.e. an increased respiratory system inertance Irs, result in a significant inertive pressure contribution. The aim of this study was to develop a physical inertance model, and its description by conventional methods of respiratory monitoring. Its parameters are adjustable within the physiological range, with Irs between 0.06 and 0.2 mbar·s2·l−1. The model proved well with static and dynamic analysis of respiratory system parameters. Using our physical model it is possible to evaluate new methods of respiratory monitoring and to investigate experimentally the interrelationship of respiratory system parameters.
Keywords: ARDS, compliance, multiple linear regression, resistance, respiratory system mechanics
